Transfer factor 1993: New frontiers

A review on transfer factor an immune modulator

“…4e6 The positive responses are confirmed through various tests such as delayed hypersensitivity test on skin, response to alloantigen, specific and non-specific mitogen, type of T cell, NK cell activity, cytokines activity. Since, transfer factors are acquired in our bodies through natural immune system and able to perform catalytic function in immune system triggering effect without getting consumed, 4 this review aimed to provide briefly its mechanism of action once synthesized, immunological role in aiding cell mediated immunity as it is having extraordinary benefits.…”

Dialyzable Leukocyte Extract differentially regulates the production of TNF?, IL-6, and IL-8 in bacterial component-activated leukocytes and endothelial cells

“…Dialyzable Leukocyte Extract (DLE) is derived from immune leukocytes and contains low molecular weight moieties (<10.000 Da) [1,2]. This preparation is a modulator of the immune response capable of transferring specific immunity to naive T cells [3], that also inhibits the production of TNFa by monocytes [4].…”

“…This preparation is a modulator of the immune response capable of transferring specific immunity to naive T cells [3], that also inhibits the production of TNFa by monocytes [4]. DLE has been reported to be effective in various pathologies caused by viral, parasitic, fungal and mycobacterial infections (see for review [2]). Particularly, DLE was used with great success in the treatment of herpes and HIV infections, asthma, rheumatoid arthritis, recurrent respiratory infections, and atopic dermatitis [5,6].…”

Immunotherapy with Dialyzable Leukocyte Extracts Containing Transfer Factor

“…The first TF-preparations were obtained in the laboratory of Dr. Lawrence [4] though dialysis of human leukocyte cryolysates. Furthermore, dialysis as a separation method of low-molecular-weight components was replaced by ultrafiltration [8,26,30]. Membrane filters with a cutoff of <12 kDa are used in the procedure.…”

“…Since cellmediated immunity (CMI) is crucial for controlling infections, as well as cancer, autoimmune diseases, immunodeficiencies and allergies, the transfer factor can be used in the treatment of these cases [1,3,[7][8][9][10].…”