Transfer and Integration of Breast Milk Stem Cells to the Brain of Suckling Pups

Aydın, Mehmet; Yiğit, Esra Nur; Vatandaşlar, Emre; Erdoğan, Ender; Öztürk, Gürkan

doi:10.1038/s41598-018-32715-5

Cited by 60 publications

(52 citation statements)

References 59 publications

(70 reference statements)

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“…Identifying the amount of cortisol that diffuses through the gut may help to further examine the potential effects of this hormone on infant health and behavior. Candidate methods to obtain this information would be to use in vitro evaluation methods to assess the passage of cortisol through the intestinal barrier [64], or in vivo rodent models with labelled cortisol to assess the amount of cortisol that reaches offspring blood circulation and brain [65,66].…”

Section: Plos Onementioning

confidence: 99%

Human milk cortisol and immune factors over the first three postnatal months: Relations to maternal psychosocial distress

Aparicio¹,

Browne²,

Hechler³

et al. 2020

PLoS ONE

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Background Many biologically active factors are present in human milk including proteins, lipids, immune factors, and hormones. The milk composition varies over time and shows large inter-individual variability. This study examined variations of human milk immune factors and cortisol concentrations in the first three months post-partum, and their potential associations with maternal psychosocial distress. Methods Seventy-seven healthy mothers with full term pregnancies were enrolled, of which 51 mothers collected morning milk samples at 2, 6 and 12 weeks post-delivery. Maternal psychosocial distress was assessed at 6 weeks post-delivery using questionnaires for stress, anxiety, and depressive symptoms. Immune factors were determined using multiplex immunoassays and included innate immunity factors (IL1β, IL6, IL12, IFNγ, TNFα), acquired immunity factors (IL2, IL4, IL10, IL13, IL17), chemokines (IL8, Groα, MCP1, MIP1β), growth factors (IL5, IL7, GCSF, GMCSF, TGFβ2) and immunoglobulins (IgA, total IgG, IgM). Cortisol was quantified using liquid chromatography-tandem mass spectrometry. A linear mixed effects model was fit to test whether stress, anxiety, and depressive symptoms individually predicted human milk cortisol concentrations after accounting for covariates. Repeated measurement analyses were used to compare women with high (n = 13) versus low psychosocial distress (n = 13) for immune factors and cortisol concentrations. Results Virtually all immune factors and cortisol, with the exception of the granulocyte-macrophage colony-stimulating factor (GMCSF), were detected in the human milk samples. The

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Section: Plos Onementioning

confidence: 99%

Human milk cortisol and immune factors over the first three postnatal months: Relations to maternal psychosocial distress

Aparicio¹,

Browne²,

Hechler³

et al. 2020

PLoS ONE

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“…It even contains maternal cells that integrate into the infant's gut walls creating localized microchimerism ensuring proper immunity development for the infant (Moles et al., ). Moreover, in mice, maternal milk stem cells were detected in the blood and the brain of the pups after sucking (Aydin, Yigit, Vatandaslar, Erdogan, & Ozturk, ). These cells differentiated into neuronal and glial cells in the progeny confirming previous in vitro experiments where these stem cells differentiated into oligodendrocytes, astrocytes, and neurons (Hosseini, Talaei‐Khozani, Sani, & Owrangi, ).…”

Section: Micrornas In Milkmentioning

confidence: 99%

Milk MicroRNAs in Health and Disease

Benmoussa

Provost

2019

Comp Rev Food Sci Food Safe

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MicroRNAs are small noncoding RNAs responsible for regulating 40% to 60% of gene expression at the posttranscriptional level. The discovery of circulating microRNAs in several biological fluids opened the path for their study as biomarkers and long‐range cell‐to‐cell communication mediators. Their transfer between individuals in the case of blood transfusion, for example, and their high enrichment in milk have sparked the interest for microRNA transfer through diet, especially from mothers to infants during breastfeeding. The extension of such paradigm led to the study of milk microRNAs in the case of cow or goat milk consumption in adults. Here we provide a comprehensive critical review of the key findings surrounding milk microRNAs in human, cow, and goat milk among other species. We discuss the data on their biological properties, their use as disease biomarkers, their transfer between individuals or species, and their putative or verified functions in health and disease of infants and adult consumers. This work is based on all the literature available and integrates all the results, theories, debates, and validation studies available so far on milk microRNAs and related areas of investigations. We critically discuss the limitations and outline future aspects and avenues to explore in this rapidly growing field of research that could impact public health through infant milk formulations or new therapies. We hope that this comprehensive review of the literature will provide insight for all teams investigating milk RNAs’ biological activities and help ensure the quality of future reports.

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“…Preclinical studies demonstrate that hBSCs cross the neonatal gut, enter the circulation, and travel into various organs where they differentiate and become functional. 62,63 Stem cells are destroyed by freezing or heating MOM, supporting the importance of feeding fresh MOM to infants.…”

Section: Bioactive Componentsmentioning

confidence: 99%

Racial and socioeconomic disparities in breast milk feedings in US neonatal intensive care units

2020

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Transfer and Integration of Breast Milk Stem Cells to the Brain of Suckling Pups

Cited by 60 publications

References 59 publications

Human milk cortisol and immune factors over the first three postnatal months: Relations to maternal psychosocial distress

Human milk cortisol and immune factors over the first three postnatal months: Relations to maternal psychosocial distress

Milk MicroRNAs in Health and Disease

Racial and socioeconomic disparities in breast milk feedings in US neonatal intensive care units

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