Transfer and distribution of Niobium-95 in adult, fetal, and newborn rats after injection during pregnancy

Schneidereit, M.; Senekowitsch, R.; Kriegel, H.

doi:10.1007/bf01229818

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…As predicted by Cuddihy’s model, whole-body retention was 44% at 8 d and 28% at 128 d following acute input of stable niobium to blood. The predicted bone contents at these two times were approximately 14% and 16%; the liver contents were 9% and 8%; contents of other soft tissues were 17% and 6%; cumulative urinary losses were 45% and 60%; and cumulative faecal losses were 5% and 10%. (616) Following intravenous administration of 95 Nb oxalate to pregnant rats, there was a slow decrease in the activity concentrations in blood and liver during the first day and a simultaneous increase in kidneys and bone (Schneidereit et al., 1985). Whole-body retention over the first 20 d after injection into dams was described as the sum of two exponential terms with biological half-times of 1.3 d (∼30%) and 46 d (∼70%).…”

Section: Niobium (Z = 41)mentioning

confidence: 99%

“…(616) Following intravenous administration of 95 Nb oxalate to pregnant rats, there was a slow decrease in the activity concentrations in blood and liver during the first day and a simultaneous increase in kidneys and bone (Schneidereit et al., 1985). Whole-body retention over the first 20 d after injection into dams was described as the sum of two exponential terms with biological half-times of 1.3 d (∼30%) and 46 d (∼70%).…”

Section: Niobium (Z = 41)mentioning

confidence: 99%

See 1 more Smart Citation

ICRP Publication 134: Occupational Intakes of Radionuclides: Part 2

Paquet¹,

Bailey²,

Leggett³

et al. 2016

Ann ICRP

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The 2007 Recommendations of the International Commission on Radiological Protection (ICRP, 2007) introduced changes that affect the calculation of effective dose, and implied a revision of the dose coefficients for internal exposure, published previously in the Publication 30 series (ICRP, 1979, 1980, 1981, 1988b) and Publication 68 (ICRP, 1994b). In addition, new data are available that support an update of the radionuclide-specific information given in Publications 54 and 78 (ICRP, 1988a, 1997b) for the design of monitoring programmes and retrospective assessment of occupational internal doses. Provision of new biokinetic models, dose coefficients, monitoring methods, and bioassay data was performed by Committee 2, Task Group 21 on Internal Dosimetry, and Task Group 4 on Dose Calculations. A new series, the Occupational Intakes of Radionuclides (OIR) series, will replace the Publication 30 series and Publications 54, 68, and 78. Part 1 of the OIR series has been issued (ICRP, 2015), and describes the assessment of internal occupational exposure to radionuclides, biokinetic and dosimetric models, methods of individual and workplace monitoring, and general aspects of retrospective dose assessment. The following publications in the OIR series (Parts 2–5) will provide data on individual elements and their radioisotopes, including information on chemical forms encountered in the workplace; a list of principal radioisotopes and their physical half-lives and decay modes; the parameter values of the reference biokinetic model; and data on monitoring techniques for the radioisotopes encountered most commonly in workplaces. Reviews of data on inhalation, ingestion, and systemic biokinetics are also provided for most of the elements. Dosimetric data provided in the printed publications of the OIR series include tables of committed effective dose per intake (Sv per Bq intake) for inhalation and ingestion, tables of committed effective dose per content (Sv per Bq measurement) for inhalation, and graphs of retention and excretion data per Bq intake for inhalation. These data are provided for all absorption types and for the most common isotope(s) of each element. The electronic annex that accompanies the OIR series of reports contains a comprehensive set of committed effective and equivalent dose coefficients, committed effective dose per content functions, and reference bioassay functions. Data are provided for inhalation, ingestion, and direct input to blood. The present publication provides the above data for the following elements: hydrogen (H), carbon (C), phosphorus (P), sulphur (S), calcium (Ca), iron (Fe), cobalt (Co), zinc (Zn), strontium (Sr), yttrium (Y), zirconium (Zr), niobium (Nb), molybdenum (Mo), and technetium (Tc).

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Section: Niobium (Z = 41)mentioning

confidence: 99%

Section: Niobium (Z = 41)mentioning

confidence: 99%

ICRP Publication 134: Occupational Intakes of Radionuclides: Part 2

Paquet¹,

Bailey²,

Leggett³

et al. 2016

Ann ICRP

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show abstract

“…There is little direct information on the biokinetics of niobium in humans, but the systemic behaviour of niobium has been studied in a variety of laboratory animals, including dogs (Furchner andDrake 1971, Cuddihy 1978), monkeys (Furchner and Drake 1971), swine (Mraz and Eisele 1977), sheep (Mraz and Eisele 1977), guinea pigs (Harrison et al 1990), rats (Hamilton 1948, Durbin et al 1957, Durbin 1960, Rama Sastry et al 1964, Matthews and Gartside 1965, Semenov et al 1966, Razumovskiĭ et al 1966, Fletcher 1969, Furchner and Drake 1971, Schneidereit et al 1985, and mice (Bäckström et al 1967, Furchner and Drake 1971, Gachalyi et al 1987. The data suggest that the systemic behaviour of niobium does not depend strongly on the mammalian species or mode of intake.…”

Section: Niobiummentioning

confidence: 99%

Biokinetic models for Group VB elements

Leggett¹,

O’Connell²

2018

J. Radiol. Prot.

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This paper reviews biokinetic data for the Group VB elements vanadium, niobium, and tantalum, and presents biokinetic models describing their systemic behaviour. The model for systemic niobium in adults was developed earlier and described in Publication 134 of the International Commission on Radiological Protection. The model for niobium is used as a starting point for the development of models for vanadium and tantalum. Published biokinetic data for vanadium, including comparisons with niobium, indicate that the initial distribution of vanadium is broadly similar to that of niobium but that vanadium is less firmly fixed in most tissues and is excreted more rapidly than niobium. Biokinetic data for tantalum are more limited but suggest that its systemic behaviour closely resembles that of niobium at early times after administration. The model for niobium is proposed for application to tantalum in view of the suggested biological similarities of tantalum and niobium, their generally strong coherence in nature due to similar ionic radii and identical valence states, and the difficulties in developing parameter values directly from available data for tantalum. The proposed model for vanadium relies largely on vanadium-specific information and varies considerably from the model for niobium.

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“…Different studies have defined the concentration in organs by using radioactive niobium (gSNb) (a by-product of fissionable materials) (Haley et al 1962, Furchner & Drake 1971, Schneidereit et al 1985 The aim of this study, using an X-ray electron probe microanalyzer equipped with a transmission electron microscope, was to investigate alterations induced by the administration of niobium salt at the subcellular level as well as the ultrastructural localization of the salt in intracellular organelles of kidney and bone marrow cells.…”

Section: Introductionmentioning

confidence: 99%

Selective intra-lysosomal concentration of niobium in kidney and bone marrow cells: a microanalytical study

1993

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Niobium is used as an alloy in the industrial and biomedical fields. The concentration of the toxic element in organs of a number of animal species has been defined by using radioactive niobium (95Nb). However, tissue lesions induced by niobium have only been studied at the light microscopy level. In this study, we used an electron probe X-ray analyzer equipped with a transmission electron microscope to define the localization of this element in kidney and bone marrow cells. Results demonstrated that niobium is located in the lysosome and that this element coprecipitates with phosphate. In kidney, lysosomes and precipitates are eliminated in the tubular lumen. In contrast, precipitates appear to be eliminated more slowly from the lysosomes of bone marrow macrophages. These processes therefore correspond to one of the mechanisms by which lysosomes eliminate certain toxic mineral elements and thus play a role in the more general process of the body's defenses.

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Transfer and distribution of Niobium-95 in adult, fetal, and newborn rats after injection during pregnancy

Cited by 6 publications

References 10 publications

ICRP Publication 134: Occupational Intakes of Radionuclides: Part 2

ICRP Publication 134: Occupational Intakes of Radionuclides: Part 2

Biokinetic models for Group VB elements

Selective intra-lysosomal concentration of niobium in kidney and bone marrow cells: a microanalytical study

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