Transepidermal Drug Delivery

Issa, Maria Claudia Almeida; Casabona, Gabriela; Torreão, Paulo Santos; Roale, Livia

doi:10.1007/978-3-319-12589-3_31

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Transepidermal drug delivery has been developed to increase the penetration of drugs through the superficial layers of the skin 6 . The microneedling technique is used as a way to trespass the stratum corneum to deliver active ingredients to the skin in a more efficient way 7 .…”

Section: Introductionmentioning

confidence: 99%

“…5 Transepidermal drug delivery has been developed to increase the penetration of drugs through the superficial layers of the skin. 6 The microneedling technique is used as a way to trespass the stratum corneum to deliver active ingredients to the skin in a more efficient way. 7 In addition, these microneedles create microinjuries and activate wound healing cascade with release of various factors including platelet-derived growth factor (PGF), transforming growth factor alpha and beta (TGFα and TGFβ), connective tissue-activating protein, connective tissue growth factor, and fibroblast growth factor (FGF).…”

Section: Introductionmentioning

confidence: 99%

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Different methods of enhancing the efficacy of topical tacrolimus in extra‐facial vitiligo: A comparative study

Esmat

Gawdat

Hegazy

et al. 2021

J of Cosmetic Dermatology

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Background: Vitiligo is an acquired pigmentation disorder due to loss of melanocytes. Topical tacrolimus is effective in vitiligo treatment with minimal effect on extra-facial lesions. Objective: To assess different methods of enhancing the absorption of topical tacrolimus in extra-facial vitiligo sites using microneedling and occlusion. Methods: This study included 20 adult patients of both sexes with non-segmental vitiligo. Four extra-facial vitiligo lesions in each patient were randomly labeled A, B, C, and D and treated as follows: area A: tacrolimus ointment (0.03%) application twice/day, area B: microneedling once/week and tacrolimus ointment application directly after microneedling and twice/day the rest of the week, area C: microneedling once/week alone, and area D: tacrolimus ointment application twice/day under occlusion by polyethylene foil. The evaluation was done clinically by calculating the repigmentation percent after 6 months of treatment. Results: Responders in area B were 45%, and 35% in area C, and 25% in both areas A and D. No statistically significant difference was detected regarding the repigmentation percent between the four areas (p > 0.05). No correlations were detected between re-pigmentation percent and patientsˈ data. Conclusion: Combination of microneedling and topical tacrolimus has an edge over monotherapy in vitiligo, and further studies are needed to verify such results.

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Section: Introductionmentioning

confidence: 99%