Transepidermal drug delivery: A new treatment option for areata alopecia?

Issa, Maria Claudia Almeida; Pires, Marianna; Silveira, Priscilla; Brito, Esther Xavier de; Sasajima, Cristiane

doi:10.3109/14764172.2014.967778

Cited by 43 publications

(35 citation statements)

References 13 publications

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“…9,12 In addition, some lasers have been used in order to increase the skin permeability of drugs used in alopecia. 31,32 Because the sample size of the studies was small, further randomized clinical trials on larger number of patients are needed. The Korean national insurance does not cover for the use of lasers in the treatment of AA, hence limiting its uses in Korea.…”

Section: Resultsmentioning

confidence: 99%

“…31,32 Efficient topical drug delivery may be challenging due to the barrier function of the stratum corneum and laser treatment can precisely and selectively remove the stratum corneum in a controlled and noncontact manner. 33 A study was performed on nude mouse and porcine skin to evaluate whether erbium:yttrium aluminum garnet (erbium:YAG) laser may facilitate the permeability of topical medications used in alopecia.…”

Section: Lasers Used To Increase Drug Deliverymentioning

confidence: 99%

“…Complete recovery was observed in all patients with one to six sessions of treatment, depending on the clinical responses. 31 Besides the ablative effect of removing the stratum corneum, the laser may interact with sebum to break up the barrier function, increasing the skin delivery of drugs. The minimally invasive, wellcontrolled approach of laser-mediated drug permeation may offer a potential way to treat alopecia.…”

Section: Lasers Used To Increase Drug Deliverymentioning

confidence: 99%

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Use of Lasers in the Treatment of Alopecia Areata

Chu

Kim

2016

Medical Lasers

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Alopecia areata (AA) is a complex autoimmune disease characterized by round or oval patches of non-scarring hair loss that is mediated by lymphocytes affecting the hair follicles. To treat localized AA, intralesional corticosteroid injections and topical corticosteroids are most commonly used, while for widespread AA, systemic steroids, immunosuppresants, and contact immunotherapy are commonly considered. However, therapeutic options for refractory AA that is unresponsive to these conventional treatments are limited. Various lasers have been suggested in recent studies to treat AA. The effect of 308-nm excimer laser was the most studied, while others, including neodymium-doped yttrium aluminum garnet, erbium:glass laser, fractional CO2 laser, and low-level laser therapy, have also been assessed. Despite the nascent state of research on lasers as a treatment option for AA, there have been a great deal of promising results. It is possible for lasers to become the mainstay treatment option of AA. Key words

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Section: Resultsmentioning

confidence: 99%

Section: Lasers Used To Increase Drug Deliverymentioning

confidence: 99%

Section: Lasers Used To Increase Drug Deliverymentioning

confidence: 99%

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Use of Lasers in the Treatment of Alopecia Areata

Chu

Kim

2016

Medical Lasers

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“…Ablative fractional resurfacing associated with acoustic pressure ultrasound was suggested by Issa et al as a method for increasing the delivery of topical triamcinolone [52].…”

Section: Phototherapy and Laser Therapymentioning

confidence: 99%

Current and future pharmacotherapy for alopecia areata

Vázquez-Herrera

Tosti

2015

Expert Opinion on Orphan Drugs

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“…In a pilot study, two patients with alopecia areata were treated with CO 2 ‐AFXL and subsequent ultrasound‐assisted triamcinolone acetonide application, resulting in complete response of the treated area after just one single session .…”

Section: Corticosteroidsmentioning

confidence: 99%

Laser‐assisted drug delivery: mode of action and use in daily clinical practice

Braun

Schrumpf

Buhren

et al. 2016

J Deutsche Derma Gesell

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Summary Topical application of pharmaceutical agents is a basic principle of dermatological therapy. However, the effective barrier function of the skin significantly impairs the bioavailability of most topical drugs. Fractional ablative lasers represent an innovative strategy to overcome the epidermal barrier in a standardized, contact‐free manner. The bioavailability of topical agents can be significantly enhanced using laser‐assisted drug delivery (LADD). In recent years, the principle of LADD has become well established for various dermatological indications. Herein, we review the current literature on LADD and present potential future applications.

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Transepidermal drug delivery: A new treatment option for areata alopecia?

Abstract: Fractioned ablative resurfacing associated with acoustic pressure wave US is a new option to areata alopecia treatment with good clinical result and low incidence of side effects.

Cited by 43 publications

References 13 publications

Use of Lasers in the Treatment of Alopecia Areata

Use of Lasers in the Treatment of Alopecia Areata

Current and future pharmacotherapy for alopecia areata

Laser‐assisted drug delivery: mode of action and use in daily clinical practice

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