TRANSDUCTION OF THE MU‐FACTOR IN <i>ESCHERICHIA COLI</i>

Gundersen, Wenche Blix

doi:10.1111/apm.1965.65.4.621

Cited by 5 publications

(1 citation statement)

References 15 publications

(14 reference statements)

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“…R I confers resistance to streptomycin 128 pg./ml., but, at the same time, it can be seen greatly to increase the rate of appearance of highly streptomycin-resistant variants. Gundersen (1963Gundersen ( , 1965a and Ginoza & Painter (1964) observed what may be the same phenomenon, which was attributed to 'genetic instability' resulting from a 'mutator gene' present on an episome. The particular episome studied by Gundersen itself gave resistance to low concentrations of streptomycin (Gundersen, 1965 a), and Ginoza & Painter (1964) noted that the apparently mutagenic effect of R factors was limited to drugs where the R factor already conferred some degree of resistance.…”

Section: Results a N D Discussionmentioning

confidence: 92%

Mutation to High-level Streptomycin-resistance in R+ Bacteria

Pearce

Meynell

1968

Journal of General Microbiology

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Section: Results a N D Discussionmentioning

confidence: 92%

Mutation to High-level Streptomycin-resistance in R+ Bacteria

Pearce

Meynell

1968

Journal of General Microbiology

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Transferable resistance factors with mutator effect in Salmonella typhi

Sompolinski¹,

Ben-Yakov²,

Aboud³

et al. 1967

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Trimethoprim resistance controlled by a combination of plasmid and chromosomal genes

Amyes

Smith

1977

Genet. Res.

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SUMMARYR388s is a mutant of the R factor, R388. Unlike its parent R388s does not confer trimethoprim resistance, though it does confer sulphonamide resistance and the ability to transfer. It is shown that when bacteria harbour R388s mutations to trimethoprim resistance occurred at a high frequency (3·5 × 10−4), whereas such mutations never occurred when the host lacked the R factor. Bacteria harbouring R388s did not mutate to resistance to any other antibiotics at a detectable frequency.The expression of trimethoprim resistance in bacteria possessing R388s appears to require two genes, one located on the R factor and the other situated presumably on the chromosome. The mechanism of trimethoprim resistance in these bacteria is probably due to reduced permeability and is thus quite unlike the insusceptible target site mechanism of the parent R factor, R388.

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TRANSDUCTION OF THE MU‐FACTOR IN ESCHERICHIA COLI

Cited by 5 publications

References 15 publications

Mutation to High-level Streptomycin-resistance in R+ Bacteria

Mutation to High-level Streptomycin-resistance in R+ Bacteria

Transferable resistance factors with mutator effect in Salmonella typhi

Trimethoprim resistance controlled by a combination of plasmid and chromosomal genes

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