Transdiagnostic validity of the MATRICS Consensus Cognitive Battery across the autism-schizophrenia spectrum

Kuo, Susan S.; Wojtalik, Jessica A.; Mesholam-Gately, Raquelle I.; Keshavan, Matcheri S.; Eack, Shaun M.

doi:10.1017/s0033291719001582

Cited by 14 publications

(17 citation statements)

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“…Thus, if a child has a diagnosis of ASD and develops schizophrenia later on, clinicians may be less likely to diagnose it (Pina-Camacho, Parellada, & Kyriakopoulos, 2016). A recent study found transdiagnostic validity of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) across the autism-schizophrenia spectrum in adults (Kuo, Wojtalik, Mesholam-Gately, Keshavan, & Eack, 2019). The study highlights MCCB's applicability to ASD and supports its utility for standardising treatment evaluations of cognitive outcomes across the autism-schizophrenia spectrum.…”

Section: Discussionmentioning

confidence: 83%

Similar impairments shown on a neuropsychological test battery in adolescents with high-functioning autism and early onset schizophrenia: a two-year follow-up study

Øie

Andersen

Hovik

et al. 2020

Cognitive Neuropsychiatry

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Introduction: Cognitive impairments are common in both Autism Spectrum Disorders (ASD) and schizophrenia, but it is unclear whether the pattern of difficulties is similar or different in the two disorders. This cross-sectional and longitudinal study compared the neuropsychological functioning in adolescents with ASD with adolescents with Early Onset Schizophrenia (EOS). Methods: At baseline and at two-year follow-up, participants were assessed with a brief neuropsychological test battery measuring executive functions, visual and verbal learning, delayed recall and recognition and psychomotor speed. Results: We found similar levels of neuropsychological impairment across groups and over time in the adolescents with ASD or EOS. Adolescents in both groups did not improve significantly on verbal learning, verbal delayed recall, visual learning, visual delayed recall or visual delayed recognition, and both groups performed poorer on verbal recognition. Both groups improved on measures of psychomotor processing and executive functions. Conclusion: The findings suggest that it may be difficult to differentiate adolescents with EOS and ASD based on neuropsychological task performance. An implication of the results is that adolescents with either disorder may benefit from a similar approach to the treatment of cognitive impairment in the disorders.

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Section: Discussionmentioning

confidence: 83%

Similar impairments shown on a neuropsychological test battery in adolescents with high-functioning autism and early onset schizophrenia: a two-year follow-up study

Øie

Andersen

Hovik

et al. 2020

Cognitive Neuropsychiatry

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“…First, it might be argued that social cognitive measures could perform differently across clinical groups and that transdiagnostic comparisons are therefore inherently invalid. This is an important point; however, the majority of tasks utilized here have been psychometrically validated in each population (Pinkham et al ., 2016 b ; Morrison et al ., 2019), and two recent studies demonstrate that the Mayer–Salovey–Caruso Emotion Intelligence Test (MSCEIT), a well-known emotion processing assessment, and the MCCB are generalizable across ASD and SCZ with partial measurement invariance and full structural invariance (Kuo et al ., 2019 a , 2019 b ). The parallel nature of the MSCEIT and the assessments used here suggests that our measures are also transdiagnostically valid; however, this should be confirmed in future analyses.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive comparison of social cognitive performance in autism spectrum disorder and schizophrenia

et al. 2019

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BackgroundAutism spectrum disorder (ASD) and schizophrenia (SCZ) are separate neurodevelopmental disorders that are both characterized by difficulties in social cognition and social functioning. Due to methodological confounds, the degree of similarity in social cognitive impairments across these two disorders is currently unknown. This study therefore conducted a comprehensive comparison of social cognitive ability in ASD and SCZ to aid efforts to develop optimized treatment programs.MethodsIn total, 101 individuals with ASD, 92 individuals with SCZ or schizoaffective disorder, and 101 typically developing (TD) controls, all with measured intelligence in the normal range and a mean age of 25.47 years, completed a large battery of psychometrically validated social cognitive assessments spanning the domains of emotion recognition, social perception, mental state attribution, and attributional style.ResultsBoth ASD and SCZ performed worse than TD controls, and very few differences were evident between the two clinical groups, with effect sizes (Cohen's d) ranging from 0.01 to 0.34. For those effects that did reach statistical significance, such as greater hostility in the SCZ group, controlling for symptom severity rendered them non-significant, suggesting that clinical distinctions may underlie these social cognitive differences. Additionally, the strength of the relationship between neurocognitive and social cognitive performance was of similar, moderate size for ASD and SCZ.ConclusionsFindings largely suggest comparable levels of social cognitive impairment in ASD and SCZ, which may support the use of existing social cognitive interventions across disorders. However, future work is needed to determine whether the mechanisms underlying these shared impairments are also similar or if these common behavioral profiles may emerge via different pathways.

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“…Because the WAIS does not include measures of visual or verbal memory, we were unable to examine cognitive functioning in these domains. Thus, this work may be further expanded upon by using transdiagnostically validated cognitive batteries that include measures of memory, such as the MATRICS Consensus Cognitive Battery (47).…”

Section: Considerationsmentioning

confidence: 99%

Meta-Analysis of Cognitive Performance in Neurodevelopmental Disorders during Adulthood: Comparisons between Autism Spectrum Disorder and Schizophrenia on the Wechsler Adult Intelligence Scales

Kuo

Eack

2020

Front. Psychiatry

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Autism Spectrum Disorder (ASD) and schizophrenia are neurodevelopmental disorders which show substantial cognitive heterogeneity in adulthood, yet it remains unclear whether cognitive profiles may overlap across these diagnoses. Thus, the aim of this review was to summarize comparisons between ASD and schizophrenia on nonsocial cognition in adulthood. To minimize between-study heterogeneity in a relatively small literature, subtest scaled scores from the Wechsler Adult Intelligence Scale were compared between ASD (N=190) and schizophrenia (N=260) in six studies comprising a total of 450 participants. Meta-analyses of 11 subtests indicated that participants with ASD demonstrated significantly better performance than schizophrenia for visuospatial perception and reasoning and problem solving (Hedge's g=0.636), as well as visual attention and organization (g=0.433-0.475). Participants with ASD also demonstrated better performance than those with schizophrenia for working memory (g=0.334) and language (g=0.275), and generally comparable performance on processing speed and verbal comprehension. These findings were largely stable across age, sex, intelligence quotient (IQ), intellectual disability, scale version, and age-and sex-matching. Overall, ASD and schizophrenia showed striking differences in visuospatial perception and reasoning and problem solving, small differences in working memory and language, and substantial overlap in processing speed and verbal comprehension. These cognitive profiles were generally stable from adolescence to middle adulthood. To our knowledge, this is the first review to summarize comparisons of nonsocial cognition in verbal adults with ASD or schizophrenia. These findings are consistent with and substantially extend prior metaanalyses of case-control studies for ASD and schizophrenia (8, 9), which also suggest that, in comparison to neurotypical controls, ASD demonstrates smaller cognitive impairments than schizophrenia across most cognitive domains, particularly working

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Transdiagnostic validity of the MATRICS Consensus Cognitive Battery across the autism-schizophrenia spectrum

Cited by 14 publications

References 58 publications

Similar impairments shown on a neuropsychological test battery in adolescents with high-functioning autism and early onset schizophrenia: a two-year follow-up study

Similar impairments shown on a neuropsychological test battery in adolescents with high-functioning autism and early onset schizophrenia: a two-year follow-up study

Comprehensive comparison of social cognitive performance in autism spectrum disorder and schizophrenia

Meta-Analysis of Cognitive Performance in Neurodevelopmental Disorders during Adulthood: Comparisons between Autism Spectrum Disorder and Schizophrenia on the Wechsler Adult Intelligence Scales

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