Transdiagnostic psychopathology mediates the relationship between childhood sexual abuse and HIV/AIDS and other sexually transmitted infections in adulthood

Latack, Jessica A.; Rodriguez‐Seijas, Craig; Stohl, Malka; Blanco, Carlos; Hasin, Deborah S.; Eaton, Nicholas R.

doi:10.1016/j.comppsych.2015.06.002

Cited by 17 publications

(14 citation statements)

References 69 publications

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“…The vast majority of non‐interventional studies (79%) were cross‐sectional, and only 21% longitudinal. There was a large variability in study sample size, ranging from 15 participants in the smallest study to 91,199 in the largest (median: 148 participants).…”

Section: Resultsmentioning

confidence: 99%

“…Some studies reported non‐existent (e.g., DSM‐IV‐TR bipolar II disorder with psychotic features) or incorrect diagnoses (e.g., suicidality, marijuana abuse/dependence, late onset schizophrenia‐like psychosis, social anxiety disorder and social phobia as two distinct DSM‐IV disorders). Other studies included health anxiety within mental disorders, confusingly defined either as not relating to a specific diagnosis, as hypocondriasis, or as “health‐based anxiety predominant in individuals with illness anxiety disorders and somatic symptom disorders”.…”

Section: Resultsmentioning

confidence: 99%

“…The largest transdiagnostic study published to date leveraged an electronic case register to include 353 mental disorders clustered across ten spectra, representing all ICD‐10 mental disorders except organic mental disorders. About one third of the studies (35%) included at least one non‐clinical sample.…”

Section: Resultsmentioning

confidence: 99%

“…The exact definition of the transdiagnostic construct per study is provided in Table . Only a minority of constructs (36%) involved multiple processes. Most studies (81%) were descriptive in nature.…”

Section: Resultsmentioning

confidence: 99%

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Transdiagnostic psychiatry: a systematic review

et al. 2019

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The usefulness of current psychiatric classification, which is based on ICD/DSM categorical diagnoses, remains questionable. A promising alternative has been put forward as the "transdiagnostic" approach. This is expected to cut across existing categorical diagnoses and go beyond them, to improve the way we classify and treat mental disorders. This systematic review explores whether self-defining transdiagnostic research meets such high expectations. A multi-step Web of Science literature search was performed according to an a priori protocol, to identify all studies that used the word "transdiagnostic" in their title, up to May 5, 2018. Empirical variables which indexed core characteristics were extracted, complemented by a bibliometric and conceptual analysis. A total of 111 studies were included. Most studies were investigating interventions, followed by cognition and psychological processes, and neuroscientific topics. Their samples ranged from 15 to 91,199 (median 148) participants, with a mean age from 10 to more than 60 (median 33) years. There were several methodological inconsistencies relating to the definition of the gold standard (DSM/ICD diagnoses), of the outcome measures and of the transdiagnostic approach. The quality of the studies was generally low and only a few findings were externally replicated. The majority of studies tested transdiagnostic features cutting across different diagnoses, and only a few tested new classification systems beyond the existing diagnoses. About one fifth of the studies were not transdiagnostic at all, because they investigated symptoms and not disorders, a single disorder, or because there was no diagnostic information. The bibliometric analysis revealed that transdiagnostic research largely restricted its focus to anxiety and depressive disorders. The conceptual analysis showed that transdiagnostic research is grounded more on rediscoveries than on true innovations, and that it is affected by some conceptual biases. To date, transdiagnostic approaches have not delivered a credible paradigm shift that can impact classification and clinical care. Practical "TRANSD"iagnostic recommendations are proposed here to guide future research in this field.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Transdiagnostic psychiatry: a systematic review

et al. 2019

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“…They reflect additive genetic variance [61, 62], but also connect mental disorders to environmental stressors [57, 63–66]. Additionally, they account for the link between mental disorders and important outcomes [51, 64, 67–69]. These qualities make transdiagnostic factors potentially very informative constructs for better understanding the link between comorbidity and treatment utilization.…”

Section: Introductionmentioning

confidence: 99%

Mental disorder comorbidity and treatment utilization

Rodriguez‐Seijas

Eaton

Stohl

et al. 2017

Comprehensive Psychiatry

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Objective Effective interventions have been developed for myriad common psychological and substance use disorders, though they remain highly underutilized. Previous research has shown that the likelihood of treatment utilization varies across disorder diagnosis. However, studies that focus on individual disorders have resulted in a large, piecemeal literature that neglects the high rates of multivariate comorbidity. The current study investigated the association between treatment utilization and transdiagnostic comorbidity factors. Method In a nationally representative sample of the United States adult population (N=34,653), we applied the internalizing-externalizing latent comorbidity model to examine its association with lifetime utilization of various treatments for mood, anxiety, and substance use disorders. Results Both internalizing and externalizing transdiagnostic factors were positively associated with all forms of treatment utilization. Stronger within-domain domain (e.g., internalizing’s association with mood or anxiety treatment) than between-domain (e.g., internalizing’s association with substance use disorder treatment) associations were found. Significant antagonistic internalizing-by-externalizing interactions were also observed. Conclusions These results underscore the importance of applying a nuanced approach to modeling comorbidity when predicting treatment utilization. Clinical implications are discussed.

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Adverse Childhood Experiences and HIV Risk Behaviors in Young Adult Afghan Immigrants to Eastern Iran

Naserirad

2019

Glob Soc Welf

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Transdiagnostic psychopathology mediates the relationship between childhood sexual abuse and HIV/AIDS and other sexually transmitted infections in adulthood

Cited by 17 publications

References 69 publications

Transdiagnostic psychiatry: a systematic review

Transdiagnostic psychiatry: a systematic review

Mental disorder comorbidity and treatment utilization

Adverse Childhood Experiences and HIV Risk Behaviors in Young Adult Afghan Immigrants to Eastern Iran

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