Transdermal theranostics

Than, Aung; Zan, Ping; Chen, Peng

doi:10.1002/viw2.21

Cited by 19 publications

(14 citation statements)

References 290 publications

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“…Skin is the readily accessible window for a wide range of theranostic purposes . The herein demonstrated transdermal therapy could also be used for other medical problems.…”

Section: Discussionmentioning

confidence: 99%

Transdermal Photothermal-Pharmacotherapy to Remodel Adipose Tissue for Obesity and Metabolic Disorders

et al. 2022

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Despite the increasing prevalence of obesity, the current medications, which act indirectly on the central nervous system to suppress appetite or on the gastrointestinal tract to inhibit fat absorption, suffer from poor effectiveness and side effects. Here, we developed a transdermal mild photothermal therapy directly acting on the root of evil (subcutaneous white adipose depot) to induce its ameliorating remodeling (browning, lipolysis, and apoptosis), based on the injectable thermoresponsive hydrogel encapsulated with copper sulfide nanodots. Further, combining pharmaceutical therapy with codelivery of mirabegron leads to a strong therapeutic synergy. This method not only ensures high effectiveness and low side effects due to localized and targeted application but also remotely creates significant improvements in systemic metabolism. Specifically, as compared to the untreated group, it totally inhibits obesity development in high-fat-diet fed mice (15% less in body weight) with decreased masses of both subcutaneous (40%) and visceral fats (54%), reduced serum levels of cholesterol (54%)/triglyceride (18%)/insulin (74%)/glucose (45%), and improved insulin sensitivity (65% less in insulin resistance index). This self-administrable method is amenable for long-term home-based treatment. Finally, multiple interconnected signaling pathways are revealed, providing mechanistic insights to develop effective strategies to combat obesity and associated metabolic disorders.

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“…Skin is the readily accessible window for a wide range of theranostic purposes . The herein demonstrated transdermal therapy could also be used for other medical problems.…”

Section: Discussionmentioning

confidence: 99%

Transdermal Photothermal-Pharmacotherapy to Remodel Adipose Tissue for Obesity and Metabolic Disorders

et al. 2022

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“…Such a strategy avoids stimulation of nociceptive nerve endings and minimizes a patient's pain experience. [3,4] down high-resting blood glucose levels. By contrast, a bolus regimen has a much more powerful but shorter-lived effect on blood sugar, making it an ideal supplement for people with diabetes to take after meals and in moments of extremely high blood sugar.…”

Section: Introductionmentioning

confidence: 99%

“…Such a strategy avoids stimulation of nociceptive nerve endings and minimizes a patient's pain experience. [ 3,4 ]…”

Section: Introductionmentioning

confidence: 99%

Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

Jamaledin

Makvandi

Yiu

et al. 2020

Advanced Therapeutics

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Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst-and sustained-release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.

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“…To overcome the limitations of the blood-based diagnosis, a recent trend in the field is the development of noninvasive or minimally invasive diagnosis based on sweat and skin interstitial fluid (ISF). [5][6][7] This advancement integrates the latest development in materials, analytic chemistry, electronics, and digital science. The representative technologies include continuous glucose monitoring systems, smartwatches, skin adhesive portable devices, etc.…”

Section: Introductionmentioning

confidence: 99%

Current Technological Trends in Transdermal Biosensing

Zhang

Yang

Shi

et al. 2022

Advanced NanoBiomed Research

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Transdermal biosensing focuses on the qualitative and quantitative collection and detection of biomarkers on and in the skin layers. In comparison to the blood‐based diagnosis, transdermal sensing technologies provide pain‐free, convenient, patient‐friendly, and infection‐avoiding methods to collect biosignals from transdermal samples such as interstitial fluid (ISF) and sweat. This article summarizes the latest trends in transdermal biosensing including the technologies and their application blueprints. Specifically, the current transdermal biosensing technologies including microneedles, microfluidics, and reverse iontophoresis are introduced first. Subsequently, their roles in daily health status monitoring, disease diagnosis and therapy monitoring are discussed in detail. Finally, an overview of the future blueprints and application prospects of transdermal biosensing is provided.

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Transdermal theranostics

Cited by 19 publications

References 290 publications

Transdermal Photothermal-Pharmacotherapy to Remodel Adipose Tissue for Obesity and Metabolic Disorders

Transdermal Photothermal-Pharmacotherapy to Remodel Adipose Tissue for Obesity and Metabolic Disorders

Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

Current Technological Trends in Transdermal Biosensing

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