Transdermal Photothermal Sterilization and Abscess Elimination Research of BSA‐CuS Nanoparticles in vivo

Abstract

The treatment of subcutaneous abscess caused by drug‐resistant bacteria is facing great difficulties and receiving more attention. In this work, we employed BSA‐CuS nanoparticles as a photothermal reagent to apply photothermal therapy (PTT) to combat drug‐resistant bacteria in vitro and subcutaneous abscess in vivo. The BSA‐CuS nanoparticles were found to be stable and biocompatible without cytotoxicity toward NIH3T3 and 4T1 cells. In vitro experiments showed that three species of drug‐resistant pathogens, including Escherichia coli, Staphylococcus aureus, and Candida albicans, could be effectively sterilized under co‐incubation with BSA‐CuS nanoparticles and then irradiation with 1064 nm NIR laser via tissue penetration. BSA‐CuS nanoparticles together with 1064 nm NIR laser irradiation could also effectively diminish subcutaneous abscesses caused by drug‐resistant bacteria on mice under PTT and depth PTT without causing any serious side effects and organic damage in vivo.That is OK, thank you!

Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents

“…Albumin scaffold meanwhile ensures the chemical stability, physiological stability, dispersibility and biocompatibility of the nanoagents [ 12 – 15 ]. Some studies reported that albumin-biomineralized copper sulfide nanoparticles (BSA@Cu 2−x S NPs) have excellent photothermal transduction effect, good biocompatibility and dispersibility, as well controllable size of the nanomaterials [ 16 – 23 ]. In 2016, we have shown that BSA@Cu 2−x S NPs have a high photothermal conversion efficiency, good stability and tumor photothermal ablation capacity [ 24 ].…”