Transdermal nicotine administration enhances automatic auditory processing reflected by mismatch negativity

Inami, Rie; Kirino, Eiji; Inoue, Reiichi; Arai, Heii

doi:10.1016/j.pbb.2005.01.001

Cited by 60 publications

(45 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As MMNs are difference waveform components (deviant minus standard) derived from non-attended channel stimuli, our negative fi nding is somewhat problematic for the stimulus-fi lter hypothesis which suggests that smoking/nicotine may enhance performance by acting as a stimulus barrier, screening irrelevant stimuli from awareness, thus reducing their infl uence on goal/task-directed behaviour [7] . In two previous studies, the MMN area index was found to be increased in smoking with 7 and 21 mg/24 h transdermal nicotine patches [68] and the MMN peak latency was shortened with a 16 mg/24 h nicotine patch [69] . The latter fi nding of an MMN latency shortening was interpreted as refl ecting a reduction in the amount of time required to complete a neuronal sensory mismatch process.…”

Section: Discussionmentioning

confidence: 77%

Neural Effects of Nicotine during Auditory Selective Attention in Smokers: An Event-Related Potential Study

et al. 2006

View full text Add to dashboard Cite

Acute nicotine has been found to improve task performance in smokers after smoking abstinence, but the attentional processes mediating these improvements are unclear. Since scalp-recorded event-related potentials (ERPs) have been shown to be sensitive indicators of selective attention, the effects of acutely administered nicotine were examined on ERPs and concomitant behavioural performance measures in an auditory selective attention task. Ten (6 males) overnight smoking-abstinent cigarette smokers received nicotine gum (4 mg) in a randomized, double-blind, placebo-controlled, crossover design. In a dichotic listening task [which required participants to attend and detect (target) deviant stimuli in one ear and to ignore similar stimuli in the other ear] which included ERP recordings and assessment of response speed and accuracy measures, nicotine gum failed to alter behavioural performance or amplitudes of ERP components sensitive to selective attention [reflected in the N100 and negative difference (Nd) component] or to pre-attentive detection of acoustic change [reflected in the mismatch negativity (MMN) component]. However, nicotine did influence the speed of these voluntary selective processes, as reflected by shortened latencies of the early Nd component. The findings are discussed in relation to the stimulus filter theory of smoking, and with respect to nicotine’s actions on involuntary and controlled aspects of selective attention processes.

show abstract

Section: Discussionmentioning

confidence: 77%

Neural Effects of Nicotine during Auditory Selective Attention in Smokers: An Event-Related Potential Study

et al. 2006

View full text Add to dashboard Cite

show abstract

“…In our preliminary report [52] , in which nicotine was administered transdermally under a controlled dosage regimen, the MMN latencies were shortened after nicotine administration in healthy non-smoking adults. These effects on MMN were independent of ERP components, such as N100 and P200, reflecting an earlier stage than preattentive mismatch processing.…”

Section: Introductionmentioning

confidence: 76%

Nicotine Effects on Mismatch Negativity in Nonsmoking Schizophrenic Patients

Inami

Kirino

Inoue³

et al. 2007

Neuropsychobiology

Self Cite

View full text Add to dashboard Cite

Background: The goal of the present study is to identify the effect of nicotine on auditory automatic processing, as reflected by mismatch negativity (MMN), in nonsmoking schizophrenic patients. Methods: Ten nonsmoking schizophrenic patients and 10 healthy volunteers underwent a reference session and 2 test sessions. The test sessions involved administration of a placebo patch and a nicotine skin patch, which were counterbalanced. Nicotine was administered transdermally under controlled dosage. Results: Nicotine administration shortened the MMN latencies (at Fz on nicotine/placebo: 134.8 ± 5.7/157.6 ± 6.4 ms) in healthy volunteers. In contrast, there were no significant differences in MMN latencies in schizophrenic patients (169.6 ± 5.7/165.0 ± 6.4 ms). Conclusion: Nicotine activates and accelerates preattentive and automatic processing in healthy controls, whereas there were no such effects observed in nonsmoking patients. The impaired MMN response to nicotine administration in nonsmoking schizophrenic patients may be attributed to low nicotinic receptor function, implicated in dysregulation of the glutamatergic system.

show abstract

“…Scopolamine reduced MMNm amplitudes in response to frequency, but not to duration change (Pekkonen et al, 2001). Nicotine decreased MMN latencies and increased amplitudes (Baldeweg et al, 2006;Inami et al, 2005), but recently Knott and colleagues were not able to confirm these findings (Knott et al, in press). This may be related to a different route of nicotine administration or paradigm used.…”

Section: Bottom-up: Change Detectionmentioning

confidence: 93%

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Kenemans

Kähkönen

2010

Neuropsychopharmacol

View full text Add to dashboard Cite

This review surveys human event-related brain potential (ERP) and event-related magnetic field (ERF) approaches to psychopharmacology and psychopathology, and the way in which they complement behavioral studies and other neuroimaging modalities. The major paradigms involving ERP/ERF are P50 suppression, loudness-dependent auditory evoked potential (LDAEP), mismatch negativity (MMN), P300, mental chronometry, inhibitory control, and conflict processing (eg, error-related negativity (ERN)). Together these paradigms cover a range of more bottom-up driven to more top-down controlled processes. A number of relationships between the major neurotransmitter systems and electrocortical mechanisms are highlighted. These include the role of dopamine in conflict processing, and perceptual processing vs motor preparation; the role of serotonin in P50 suppression, LDAEP, and MMN; glutamate/NMDA and MMN; and the role of acetylcholine in P300 generation and memory-related processes. A preliminary taxonomy for these relationships is provided, which should be helpful in attuning possible new treatments or new applications of existing treatments to various disorders.

show abstract

Transdermal nicotine administration enhances automatic auditory processing reflected by mismatch negativity

Cited by 60 publications

References 51 publications

Neural Effects of Nicotine during Auditory Selective Attention in Smokers: An Event-Related Potential Study

Neural Effects of Nicotine during Auditory Selective Attention in Smokers: An Event-Related Potential Study

Nicotine Effects on Mismatch Negativity in Nonsmoking Schizophrenic Patients

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

Contact Info

Product

Resources

About