Transdermal glyceryl trinitrate in the management of primary dysmenorrhea

Abstract

The data indicate that transdermal glyceryl trinitrate, as a source of exogenous nitric oxide, is useful as a modulator of uterine contractility representing, therefore, a new and mechanistically different therapeutic alternative for the management of primary dysmenorrhea.

Traditional Chinese medicine Guizhi Fuling capsule used for therapy of dysmenorrhea via attenuating uterus contraction

“…NO could relax uterine smooth muscle (Shikano et al, 1987). Clinical study also demonstrated that NO donors could provide pain relief from dysmenorrhea (Moya et al, 2000). Our study showed that GZFLC increased significantly NO level in uterus tissue, implying the involvement of NO pathways on the relaxant effect of GZFLC.…”

Therapeutic interventions targeting the nitric oxide system: Current and potential uses in obstetrics, bone disease and erectile dysfunction

“…Other studies have found similar results (The Transdermal Nitroglycerine/Dysmenorrhoea Study Group, 1997;Moya et al, 2000). A recent study by Facchinetti et al (2002) compared transdermal nitroglycerin to the commonly used nonsteroidal anti-inflammatory drug diclofenac.…”

Increased Serum Asymmetric Dimethylarginine Levels in Primary Dysmenorrhea

“…In turn, therapeutic efficacy of NO donors in primary dysmenorrhea should be remembered, and this was also evaluated by several studies. Unfortunately, reported results are controversial; some report effective relief of pain in 90% of the patients [18] , while other report statistically superior results compared to placebo [19] ; on the other hand, few reports adduce the reduced efficacy compared to diclofenac [20] .…”