Transdermal fentanyl patch versus standard analgesia in postoperative oral submucous fibrosis patients: a triple blinded, randomised control trial

Perioperative analgesic efficacy and adverse events of fentanyl in dentistry: A systematic review

“…Another four randomized controlled trials analyzed in this systematic review investigated the perioperative analgesic efficacy of the fentanyl transdermal patch in various dental procedures (Dhasmana et al, 2009(Dhasmana et al, , 2010Nihadha et al, 2022;Todorovic et al, 2016). Nihadha et al (2022) reported that the transdermal patch demonstrated a statistically significant improvement in managing severe pain during active mouth opening behaviors in surgeries performed on patients with oral submucous fibrosis, leading to significantly improved patient compliance. Different studies corroborate the analgesic efficacy of fentanyl patches after surgeries in different areas of medicine (Khandelwal et al, 2021;Kwon et al, 2019).…”

“…Another four randomized controlled trials analyzed in this systematic review investigated the perioperative analgesic efficacy of the fentanyl transdermal patch in various dental procedures (Dhasmana et al., 2009, 2010; Nihadha et al., 2022; Todorovic et al., 2016).…”

“…These RCTs were published between 1998 and 2023 and involved a total of 674 individuals. The sample sizes ranged from a minimum of 17 (Todorovic et al, 2016) to a maximum of 128 (Agarwal et al, 2023), with follow-up periods varying from 1 h (Uhle et al, 1997) to 3 months (Nihadha et al, 2022). The majority of the RCTs were conducted in India and the United States of America, with only one study conducted in children (Agarwal et al, 2023).…”

“…In a clinical trial, the use of a low-dose fentanyl delivered through a periodontal ligament injection resulted in notably superior analgesic effects when compared to the saline placebo (Uhle et al, 1997). In all RCTs reviewed, the transdermal fentanyl patch outperformed the control group, except in the clinical trial where it was compared to ropivacaine (Dhasmana et al, 2009(Dhasmana et al, , 2010Nihadha et al, 2022;Todorovic et al, 2016). Dexmedetomidine 1 g/kg (max 100 g) and ketamine 1 mg/kg (max 100 mg).…”

“…Some individuals may have a heightened sensitivity to pain or underlying medical conditions that make them more resistant to standard pain medications, thus, fentanyl may be used in these cases to ensure adequate pain control (Cocoros et al, 2019). Besides, there are reports of other uses for pain management in oral mucositis (Demarosi et al, 2004), oral submucous fibrosis (Nihadha et al, 2022), postsurgical pain management in jaw cancer (Dhasmana et al, 2009) and pulpal analgesia (Uhle et al, 1997), among others. In dentistry, fentanyl has also been used for sedation in children (Agarwal et al, 2023;Alohali et al, 2019).…”