Transdermal Delivery of the Synthetic Cannabinoid WIN 55,212-2: In Vitro/in Vivo Correlation

Abstract

The topical drug treatments provided significant steady-state plasma drug levels for 48 h. The observed in vivo results from the Hill Top Chambers and TTS patches in the guinea pigs were in good agreement with the predicted plasma concentrations from the in vitro data.

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour

“…Mean±SEM pounds. Towards this end, we reasoned that our compounds concurred with other cannabinoid agonists/antagonists such as WIN55,212-2 or rimonabant (SR141716A) (Valiveti et al 2004; Barna et al 2009) in that their absorption might be rapid and complete washout be achieved within 24 h. This assumption guided our time point selection for tissue harvesting. A second consideration pertained to the selection of vehicle for the highly lipophilic cannabinoids.…”

Improved Cardiac and Neurologic Outcomes With Postresuscitation Infusion of Cannabinoid Receptor Agonist WIN55, 212-2 Depend on Hypothermia in a Rat Model of Cardiac Arrest*

“…Our previous studies have demonstrated that the WIN55, 212-2 induced mild hypothermia and improved the outcome of cardiopulmonary resuscitation (CPR) in a rat model of cardiac arrest (9). The cooling effect of WIN55, 212-2 was rapid and long lasting due to its short mean distribution half-life (0.12 hr) and long mean terminal elimination half-life (4.93 hr) (10).…”

In Vitro/in Vivo Correlation of Transdermal Naltrexone Prodrugs in Hairless Guinea Pigs

“…Hence, in vitro studies across EVA copolymer membrane-PSA were completed. Literature reports have shown that EVA membrane (CoTran 9715, 19% w/w of vinyl acetate content) (14,22) laminated with PSA provides very high drug flux rates, as compared to other membrane choices. Hence, in the present study CoTran 9715 laminated with PSA was chosen as a membrane for the fabrication of the patches, where the drug solution was sandwiched between this membrane and the backing membrane.…”