Transdermal delivery of proteins mediated by non‐covalently associated arginine‐rich intracellular delivery peptides

Hou, Yu-Wun; Chan, Ming‐Huan; Hsu, Hui-Ru; Liu, Betty Revon; Chen, Chung‐Pin; Chen, Hwei-Hsien; Lee, Han-Jung

doi:10.1111/j.1600-0625.2007.00622.x

Cited by 85 publications

(62 citation statements)

References 37 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hou et al (2007) found that some arginine-rich intracellular delivery (AID) peptides (TAT, R9, R9Z and SR9) could enhance the delivery of green fluorescent protein (GFP) in the animal skin without conjugation with the transported protein. The best permeation ability of the cargo protein and AID (SR9) mixture into cells was achieved with a ratio of 1:3.…”

Section: Non-conjugated Peptidesmentioning

confidence: 99%

Biomaterials as novel penetration enhancers for transdermal and dermal drug delivery systems

2013

View full text Add to dashboard Cite

The highly organized structure of the stratum corneum provides an effective barrier to the drug delivery into or across the skin. To overcome this barrier function, penetration enhancers are always used in the transdermal and dermal drug delivery systems. However, the conventional chemical enhancers are often limited by their inability to delivery large and hydrophilic molecules, and few to date have been routinely incorporated into the transdermal formulations due to their incompatibility and local irritation issues. Therefore, there has been a search for the compounds that exhibit broad enhancing activity for more drugs without producing much irritation. More recently, the use of biomaterials has emerged as a novel method to increase the skin permeability. In this paper, we present an overview of the investigations on the feasibility and application of biomaterials as penetration enhancers for transdermal or dermal drug delivery systems.

show abstract

Section: Non-conjugated Peptidesmentioning

confidence: 99%

Biomaterials as novel penetration enhancers for transdermal and dermal drug delivery systems

2013

View full text Add to dashboard Cite

show abstract

“…The cell-penetrating peptides interact with lipids in the SC, thus destabilizing the outermost layer of the skin and enhancing permeability. 117,118 Conjugation of Pep-1 peptides to TRS remarkably increased the delivery of liposomal drugs into human keratinocytes (HaCaT) when compared to Tr alone. 119 TXG-Pep1-Tr treatment significantly expedited recovery in skin barrier function when compared to animals treated with TXG aqueous solution.…”

Section: Preclinical Applications As Antiscarring Anti-atopic Dermatmentioning

confidence: 99%

Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

Romero¹,

Morilla²

2013

IJN

View full text Add to dashboard Cite

Vesicles that are specifically designed to overcome the stratum corneum barrier in intact skin provide an efficient transdermal (systemic or local) drug delivery system. They can be classified into two main groups according to the mechanisms underlying their skin interaction. The first group comprises those possessing highly deformable bilayers, achieved by incorporating edge activators to the bilayers or by mixing with certain hydrophilic solutes. The vesicles of this group act as drug carriers that penetrate across hydrophilic pathways of the intact skin. The second group comprises those possessing highly fluid bilayers, owing to the presence of permeation enhancers. The vesicles of this group can act as carriers of drugs that permeate the skin after the barrier of the stratum corneum is altered because of synergistic action with the permeation enhancers contained in the vesicle structure. We have included a detailed overview of the different mechanisms of skin interaction and discussed the most promising preclinical applications of the last five years of Transfersomes ® (IDEA AG, Munich, Germany), ethosomes, and invasomes as carriers of antitumoral and anti-inflammatory drugs applied by the topical route.

show abstract

“…Topical administration of several peptides would be attractive, including IGF-1, TGF-b, leptin, 14-3-3 proteins (for wound healing), interferon a (antiviral), cyclosporine (for treatment for autoimmune diseases), bacitracin (for skin infections), and palmitoylglycyl-histidyl-lysine tripeptide (for stimulation of collagen synthesis), among many others (39,(78)(79)(80)(81)(82)(83). In addition, several peptides have been applied to the skin and studied as antigens for the development of topical vaccines (84).…”

Section: Transdermal Delivery With Cppsmentioning

confidence: 99%

Cell‐penetrating Peptides as a Novel Transdermal Drug Delivery System

et al. 2012

View full text Add to dashboard Cite

In the last decade, almost one-third of the newly discovered drugs approved by the US FDA were biomolecules and biologics. Effective delivery of therapeutic biomolecules to their target is a challenging issue. Innovations in drug delivery systems have improved the efficiency of many of new biopharmaceuticals. Designing of novel transdermal delivery systems has been one of the most important pharmaceutical innovations, which offers a number of advantages. The cell-penetrating peptides have been increasingly used to mediate delivery of bimolecular cargoes such as small molecules, small interfering RNA nucleotides, drug-loaded nanoparticles, proteins, and peptides, both in vitro and in vivo, without using any receptors and without causing any significant membrane damage. Among several different drug delivery routes, application of cell-penetrating peptides in the topical and transdermal delivery systems has recently garnered tremendous attention in both cosmeceutical and pharmaceutical research and industries. In this review, we discuss history of cell-penetrating peptides, cell-penetrating peptide ⁄ cargo complex formation, and their mechanisms of cell and skin transduction.

show abstract

Transdermal delivery of proteins mediated by non‐covalently associated arginine‐rich intracellular delivery peptides

Cited by 85 publications

References 37 publications

Biomaterials as novel penetration enhancers for transdermal and dermal drug delivery systems

Biomaterials as novel penetration enhancers for transdermal and dermal drug delivery systems

Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

Cell‐penetrating Peptides as a Novel Transdermal Drug Delivery System

Contact Info

Product

Resources

About