Transdermal Delivery of Insulin Using Combination of Iontophoresis and Deep Eutectic Solvents as Chemical Penetration Enhancers: In Vitro and in Vivo Evaluations

Khamoushian, Soroush; Madrakian, Tayyebeh; Afkhami, Abbas; Ghoorchian, Arash; Ghavami, Saeid; Tari, Kamran; Samarghandi, Mohammad Reza

doi:10.1016/j.xphs.2023.03.005

Cited by 4 publications

(1 citation statement)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a new paper, DESs were introduced as novel chemical penetration enhancers for transdermal iontophoresis of insulin across rat skin. The results of the in vivo studies indicated a reduction in the blood glucose level in diabetic rats using ChCl/ethylene glycol and ChCl/glycerol in the iontophoresis delivery of insulin [86].…”

Section: Animal Modelsmentioning

confidence: 96%

Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?

et al. 2023

View full text Add to dashboard Cite

Therapeutic Deep Eutectic Systems (THEDESs) are a mixture of components, including an active pharmaceutical ingredient, that have recently emerged because of their interesting properties for drug therapies. In general, they have been recognized to increase the solubility and permeability of some drugs, and consequently, their bioavailability. Moreover, they have also been used for novel formulations of pharmaceuticals. Despite the potential benefits of THEDESs, concerns about their safety and toxicity remain. In this review, we summarize previous studies that have investigated the toxicity of THEDESs. These studies evaluate the toxicity of THEDESs using various methods, including cell cultures, animal models, and human trials. The results of previous findings suggest that THEDESs are generally well-tolerated and have low toxicity. However, further research is needed to fully understand the long-term effects of these systems on human health and to identify any potential adverse effects.

show abstract

Section: Animal Modelsmentioning

confidence: 96%

Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?

et al. 2023

View full text Add to dashboard Cite

show abstract

Non-Invasive Delivery of Insulin for Breaching Hindrances against Diabetes

Sarangi,

Padhi,

Rath

2024

Crit Rev Ther Drug Carrier Syst

View full text Add to dashboard Cite

Insulin is recognized as a crucial weapon in managing diabetes. Subcutaneous (s.c.) injections are the traditional approach for insulin administration, which usually have many limitations. Numerous alternative (non-invasive) slants through different routes have been explored by the researchers for making needle-free delivery of insulin for attaining its augmented absorption as well as bioavailability. The current review delineating numerous pros and cons of several novel approaches of non-invasive insulin delivery by overcoming many of their hurdles. Primary information on the topic was gathered by searching scholarly articles from PubMed added with extraction of data from auxiliary manuscripts. Many approaches (discussed in the article) are meant for the delivery of a safe, effective, stable, and patient friendly administration of insulin via buccal, oral, inhalational, transdermal, intranasal, ocular, vaginal and rectal routes. Few of them have proven their clinical efficacy for maintaining the glycemic levels, whereas others are under the investigational pipe line. The developed products are comprising of many advanced micro/nano composite technologies and few of them might be entering into the market in near future, thereby garnishing the hopes of millions of diabetics who are under the network of s.c. insulin injections.

show abstract

Paper battery powered iontophoresis microneedles patch for hypertrophic scar treatment

Jiang,

Gao,

Chen

et al. 2024

Preprint

View full text Add to dashboard Cite

Hypertrophic scar (HS) is a plaque fibrous and indurated dermal lesion that may cause physical, psychological, and cosmetic challenges for patients. Intralesional injection of triamcinolone acetonide (TA) is commonly used in clinical practice, which cause unbearable pain and uneven drug delivery within HS tissue. Herein, we developed a paper battery powered iontophoresis-driven microneedle patch (PBIMNP) for self-management and painless treatment of HS. The high integration of PBIMNP was achieved by incorporating a paper battery as the power source for iontophoresis. The transdermal drug delivery strategy of PBIMNP combined microneedles and iontophoresis techniques, involving "pressing and poking, phase transformation, and diffusion and iontophoresis", which can actively deliver 90.19% drug into the HS tissue with excellent in vitro drug permeation performance. PBIMNP administration effectively reduced the mRNA and protein levels, leading to a decrease in the expression of TGF-β1 and Col I associated with HS formation, demonstrating its efficacy in HS treatment. The painless microneedles and wearable design endow the PBIMNP as a highly promising platform for self-administration on HS treatment.

show abstract

Transdermal Delivery of Insulin Using Combination of Iontophoresis and Deep Eutectic Solvents as Chemical Penetration Enhancers: In Vitro and in Vivo Evaluations

Cited by 4 publications

References 73 publications

Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?

Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?

Non-Invasive Delivery of Insulin for Breaching Hindrances against Diabetes

Paper battery powered iontophoresis microneedles patch for hypertrophic scar treatment

Contact Info

Product

Resources

About