Transdermal delivery of forskolin from emulsions differing in droplet size

Sikora, Elżbieta; Llinàs, Meritxell; García-Celma, María José; Escribano, Elvira; Solans, Conxita

doi:10.1016/j.colsurfb.2015.01.008

Cited by 10 publications

(9 citation statements)

References 33 publications

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“…The percentage of permeation after 24 h was high (69.92±8.89%, 71.49±7.11% and 83.48±7.41%, for NE1F, NE2F and MCT, respectively). These results are similar to those obtained in our previous work with emulsion composed of MCT but with different surfactant and droplet size (Sikora et al, 2015). We hypothe-size a rapid penetration of forskolin through the stratum corneum (SC) facilitated by the high lipophilicity of the molecule (logP=3.89) and adequate molecular weight (410.50 g • mol -1 ).…”

Section: Permeation Resultssupporting

confidence: 90%

“…In our previous work, we reported forskolin skin permeation from O/W emulsions with the same composition but differing in droplet size (10 mm and 380 nm) (Sikora et al, 2015). Both, macro-and nano-emulsion were prepared by a high-energy method.…”

Section: Introductionmentioning

confidence: 99%

“…Study of forskolin skin permeation. As in the previous work (Sikora et al, 2015), the in vitro skin permeation studies using the MicroettePlus ® system (Hanson Research, USA) were carried out. The experiments were performed at 32°C±0.5, 400 rpm, and using a mixture of PBS pH=7.4/ethanol (60/40, v/v) as the receptor medium.…”

Section: Introductionmentioning

confidence: 99%

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Nano-emulsions as vehicles for topical delivery of forskolin

et al. 2017

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Two O/W forskolin-loaded nano-emulsions (0.075% wt.) based on medium chain triglycerides (MCT) and stabilized by a nonionic surfactant (Polysorbate 80 or Polysorbate 40) were studied as forskolin delivery systems. The nano-emulsions were prepared by the PIC method. The mean droplet size of the nano-emulsions with Polysorbate 80 and Polysorbate 40 with oil/surfactant (O/S) ratios of 20/80 and 80% water concentration, measured by Dynamic Light Scattering (DLS), was of 118 nm and 111 nm, respectively. Stability of the formulations, as assessed by light backscattering for 24 h, showed that both nano-emulsions were stable at 25°C. Studies of forskolin in vitro skin permeation from the nano-emulsions and from a triglyceride solution were carried out at 32°C, using Franz-type diffusion cells. A mixture of PBS/ethanol (60/40 v/v) was used as a receptor solution. The highest flux and permeability coefficient was obtained for the system stabilized with Polysorbate 80 (6.91±0.75 µg · cm·h and 9.21 · 10±1.00 · 10 cm · h, respectively) but no significant differences were observed with the flux and permeability coefficient value of forskolin dissolved in oil. The obtained results showed that the nano-emulsions developed in this study could be used as effective carriers for topical administration of forskolin.

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Section: Permeation Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Nano-emulsions as vehicles for topical delivery of forskolin

et al. 2017

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“…The local use of FSK for treatment of glaucoma is being explored, too (Majeed et al, 2015). Moreover, the dermatological application of FSK to protect the skin against ultraviolet light and induce persistent tanning is under investigation (Spry et al, 2009;Scott et al, 2012;Sikora et al, 2015). Furthermore, FSK derivatives are explored as anticancer compounds (Ponnam et al, 2014).…”

Section: Clinical Applications Of Diterpenesmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Dessauer¹,

Watts²,

Ostrom³

et al. 2017

Pharmacol Rev

163

198

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“…The results showed that emulsions differing only in droplet size did not significantly differed in ability in transdermal delivery of the active substance. The permeation of forskolin from o/w emulsions and oil solution was studied by Sikora et al Two emulsions composed of water/Brij 72, Symperonic A7/Miglyol 812 and isohexadecane were prepared which differed in droplet size (0.38 and 10 μm). Transdermal penetration of forskolin from the emulsion and the oil solution through human skin was up to 72.1%; however, no effect of droplet size was observed.…”

Section: Resultsmentioning

confidence: 99%

Transdermal absorption of active substances from cosmetic vehicles

Pavlačková

Egner

Polašková

et al. 2019

J of Cosmetic Dermatology

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Summary Background Cosmetic products mean any substance or mixture intended to be placed in contact with the external parts of the human body (eg, epidermis, lips) and should not pass to the lower parts and penetrate to the skin. As a part of evaluation of cosmetic safety, the transdermal absorption of substances should be investigated. Materials and Methods In vitro absorption was investigated with Franz diffusion cells on untreated porcine skin and specimens of the same treated with 15%wt. SLS. The integrity of the skin was discerned by gauging transdermal electrical conductivity (TEC), the concentration of caffeine absorbed by the samples of skin membrane by liquid chromatography, which took place by applying an emulsion and/or a gel containing active hydration agents (urea, sodium hyaluronate, and sericin). Results The greatest extent of caffeine penetration was seen for pretreatment with just SLS; similar results were in skin treated with the base gel with 10%wt. urea. In the skin treated with the base emulsion only, the amount of caffeine absorbed was twofold less; this increased after adding the active hydration substances. The values measured for TEC corresponded with the amount of caffeine absorbed. Conclusion The gel proved to be the more potent vehicle for the active ingredient, as it demonstrated greater transdermal caffeine penetration than the emulsions, correlating with the degree of damage to the skin as detected by TEC.

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Transdermal delivery of forskolin from emulsions differing in droplet size

Cited by 10 publications

References 33 publications

Nano-emulsions as vehicles for topical delivery of forskolin

Nano-emulsions as vehicles for topical delivery of forskolin

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Transdermal absorption of active substances from cosmetic vehicles

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