Transdermal delivery of ethosomes as a novel vesicular carrier for paroxetine hydrochloride: In vitro evaluation and In vivo study

Pathan, Inayat Bashir

doi:10.12991/mpj.201620113534

Cited by 12 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Methodsmentioning

confidence: 99%

“…The PDI was determined by the same apparatus as a dimensionless number indicating the width and uniformity of the size distribution, where PDI less than 0.4 indicates a homogenous monodisperse population. 15 Zeta potential was determined using the laser-Doppler velocimetry technique using ZetaSizer. Samples were prepared by dilution of 0.1 mL of the prepared formulation with 50 mL deionized water followed by shaking for 1 minute 16 prior to measurement.…”

Section: Characterization Of the Prepared Gelatinized Core Liposomesmentioning

confidence: 99%

See 1 more Smart Citation

Augmented in vitro and in vivo Profiles of Brimonidine Tartrate Using Gelatinized-Core Liposomes

Azim¹,

Elkheshen²,

Hathout³

et al. 2022

IJN

View full text Add to dashboard Cite

Background The low entrapment efficiency of the hydrophilic drugs such as brimonidine tartrate (BRT) in liposomes represents a challenge that requires interventions. Gelatinized core liposomes (GCLs) were fabricated to increase the drug entrapment, corneal penetration, and physical stability of the investigated molecule. Research Design and Methods GCLs encapsulating BRT were prepared and optimized utilizing D-optimal design (DOD). The effect of plasticizer incorporation on the physicochemical characteristics and on the in vivo performance was studied. The optimized formulations were investigated for pH, rheological properties, morphological characteristics, in vitro release profiles, biological performance, safety profile. The effects of storage and gamma sterilization were also investigated. Results The results revealed the great success of the prepared formulations to achieve high entrapment efficiency reaching 98% after a maturation period of 10 days. The addition of glycerol as plasticizer significantly minimized the particle size and shortened the maturation period to 7 days. The selected formulations were stable for 3 months after gamma sterilization. The formulations showed significant lowering of intra-ocular pressure (IOP) in glaucomatous rabbits with sustainment of the pharmacological effect for 24 hours compared to drug solution. Conclusions Enhanced in vitro and in vivo profiles of brimonidine tartrate loaded gelatinized-core-liposomes were obtained.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Characterization Of the Prepared Gelatinized Core Liposomesmentioning

confidence: 99%

Augmented in vitro and in vivo Profiles of Brimonidine Tartrate Using Gelatinized-Core Liposomes

Azim¹,

Elkheshen²,

Hathout³

et al. 2022

IJN

View full text Add to dashboard Cite

show abstract

“…Vesicle size of OTE was found to be least (286.4 nm) as compared to that of the other formulations. PDI of OTE was 0.274 indicating homogeneous population and narrow size distribution [13]. Vesicle size was found to decrease in following order:…”

Section: Validation and Characterization Of Optimized Batchmentioning

confidence: 95%

Formulation, Systematic Optimization, in Vitro, Ex Vivo, and Stability Assessment of Transethosome Based Gel of Curcumin

Kaur

Garg

Bawa

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: The current work presents a formulation of curcumin-loaded transethosome (CRM-TE) in the form of a gel and its characterization.Methods: Thirteen formulations were prepared by varying the concentration of Phospholipon 90G as lipid, ethanol, and ratio of lipid: Span using Box- Behnken Design. The optimized formulation was characterized by vesicle size, entrapment efficiency, drug retention, drug permeation through skin, and morphology. Parameters of CRM-TE were compared to other vesicular systems that include liposomes, ethosomes, and transfersomes. Optimized CRM-TE was incorporated into gels, and comparative evaluation was performed. CRM-TE gel was kept at 5±3°C, 25±3°C, and 40±3°C for 180 days, further evaluated for entrapment efficacy and vesicle size.Results: CRM-TE showed 286.4 nm vesicle size, 61.2% entrapment efficiency, 19.8% drug retention, and 71.3% drug permeation at 24 h in the skin. It was found superior in terms of all the parameters as compared to other vesicular formulations. CRM-TE gel also exhibited best characteristics in terms of entrapment efficiency, drug retention, and drug permeation. CRM-TE gel exhibited better stability at 5±3°C in terms of vesicle size and entrapment efficiency as compared to other storage conditions.Conclusion: CRM-TE gel could offer efficient delivery of curcumin through topical route.

show abstract

“…The width of the size distribution was measured using PDI. A PDI of less than 0.4 indicates that the vesicles are homogeneous and monodisperse (Pathan et al, 2016).…”

Section: Selection Of Concentration Of Bm Seed Oil Ethanol and Phosph...mentioning

confidence: 99%

Butea monosperma seed oil loaded ethosomal vesicular carrier and its hydrogel for vaginal candidiasis: QbD based development, in vitro and in vivo evaluation

Singh,

Agarwal,

Sourirajan

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose Vaginal candidiasis (VC), a common recurrent gynaecological disorder affects almost 70% women. Development of resistance to antifungal agents exacerbates the need for new treatments against Candida infections. The objective of the current work was to develop Ethosomal Vesicles (EVs) and EV hydrogel of Butea monosperma seed oil (BMSO) for treatment of vaginal candidiasis as BMSO has demonstrated fungicidal and bactericidal activity. Methods EVs, formulated by ethanol injection-sonication method used Phospholipon90G and ethanol as excipients and were optimized by Box-Behnken design (BBD). BMSO (X1), phospholipid (X2) and ethanol concentration (X3) were selected as input variables, while vesicle size (Y1), PDI (Y2) and %EE (Y3), were taken as response variables. Results The size of optimized EVs was found to be 240.9nm, PDI was 0.326, %EE was 53.84%. FESEM and HR-TEM unveiled vesicles of rhombic dodecahedral shape with smooth, sealed structure. The EVs, incorporated into carbopol gel demonstrated non-Newtonian behavior. MIC determination by broth microdilution method revealed MIC of EVs and hydrogel to be 2.5 times less as compared to BMSO against C. albicans. Anti-candidal activities determined using agar well diffusion method demonstrated better zone of inhibition for hydrogel vis-à-vis BMSO. Pharmacodynamic evaluation manifested comparable decrease in fungal burden by EVs and EV hydrogel to marketed Clotrimazole. Histopathology of vaginal tissue of treated groups showed no or mild inflammation with normal skin structure. Conclusion The results disclosed EVs and EV hydrogel to possess better antifungal activity vis-a-vis BMSO and can be explored as potential alternative herbal product for VC.

show abstract

Transdermal delivery of ethosomes as a novel vesicular carrier for paroxetine hydrochloride: In vitro evaluation and In vivo study

Cited by 12 publications

References 9 publications

Augmented in vitro and in vivo Profiles of Brimonidine Tartrate Using Gelatinized-Core Liposomes

Augmented in vitro and in vivo Profiles of Brimonidine Tartrate Using Gelatinized-Core Liposomes

Formulation, Systematic Optimization, in Vitro, Ex Vivo, and Stability Assessment of Transethosome Based Gel of Curcumin

Butea monosperma seed oil loaded ethosomal vesicular carrier and its hydrogel for vaginal candidiasis: QbD based development, in vitro and in vivo evaluation

Contact Info

Product

Resources

About