Transdermal delivery of a pineal hormone: Melatonin via elastic liposomes

Dubey, Vaibhav; Mishra, Dinesh Kumar; Asthana, Abhay; Jain, Narendra Kumar

doi:10.1016/j.biomaterials.2006.01.060

Cited by 96 publications

(60 citation statements)

References 30 publications

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“…The transpore hydrostatic force difference is liable for the penetration or passage of transfersomes intact throughout the stratum corneum, i.e. the penetration of transfersome is an outcome of hydrotaxis and the permeation is governed by principles of elastomechanics [41]. When a transfersome reaches a pore, it is capable of changing its membrane work reversibly as an effect of its self-optimizing deformability.…”

Section: Merits/demeritsmentioning

confidence: 99%

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Rai¹,

Pandey²,

Rai³

2017

Nano Reviews & Experiments

175

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Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of edge activator, phospholipids, ethanol, and sodium cholate and are applied in a non-occlusive manner. Areas covered: This article covers information such as merits/demerits of transfersomes, regulatory aspects of materials used in preparation, different methods of preparation, mechanism of action, review of clinical investigations performed, marketed preparations available, research reports, and patent reports related to transfersomes. Expert opinion: Research over the past few years has provided a better understanding of transfersomal permeation of therapeutic agents across stratum corneum barrier. Transfersomes provides an essential feature of their application to variety of compositions in order to optimize the permeability of a range of therapeutic molecules. This is evidenced by the fact that there are several Transfersome products being processed in advanced clinical trials. It is noteworthy that a number of Transfersome products for dermal and transdermal delivery will gain a global market success in near future.

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Section: Merits/demeritsmentioning

confidence: 99%

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Rai¹,

Pandey²,

Rai³

2017

Nano Reviews & Experiments

175

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“…TEM images and electron diffraction patterns were visualized and collected by soft imaging software. 17 …”

Section: Microscopic Analysis and Transmission Electron Microscopymentioning

confidence: 99%

The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic

Singh¹,

Vardhan²,

Kotla³

et al. 2016

IJN

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Transdermal drug delivery systems have made significant contributions to the medical community, but have yet to completely substitute oral or parenteral delivery. Recently, various strategies have been used to augment the transdermal delivery of therapeutics. Primarily, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular systems. Among these strategies, elastic liposomes appear promising. Elastic vesicle scaffolds have been developed and evaluated as novel topical and transdermal delivery systems, with an infrastructure consisting of hydrophobic and hydrophilic moieties together, and as a result, such scaffolds can accommodate drug molecules with a wide range of solubility. High deformability of these vesicles provides for better penetration of intact vesicles. This system is much more efficient at delivering low- and high-molecular-weight drugs to the skin in terms of quantity and depth. In this work, elastic liposomes of Tramadol HCl were prepared using a solvent evaporation method with different surfactants and were characterized using microscopy, and particle size, shape, drug content, ex vivo release, and zeta potential were also calculated. The prepared elastic liposomes were found to be in the range of 152.4 nm with a zeta potential of −22.4 mV; the entrapment efficiencies of the selected formulation was found to be 79.71%±0.27%. All formulations in the form of a gel were evaluated for physicochemical properties and were found to be homogeneous with no grittiness, and the pH of all formulations was found to be neutral. The optimized selected elastic liposomal formulation followed the Higuchi equation and Fickian diffusion and released the drug for a period of 24 hours. The overall results provide much promise for the continued investigation of deformable vesicles as transdermal drug carriers.

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“…To improve the permeability of the drug, specially designed vesicles were proposed to allow transdermal delivery, including elastic liposomes, ethosomes, and so on. [24][25][26][27] The in vitro release rates and cumulative amount delivered are regarded as an important index of quality for a transdermal drug delivery system. According to the test results, a TP flux from the ethosomal formulation through mouse skin of 37.85 ± 2.8 µg/cm 2 /hour was calculated using the transdermal program.…”

Section: Penetration and Permeation Through The Skinmentioning

confidence: 99%

Enhanced transdermal bioavailability of testosterone propionate via surfactant-modified ethosomes

Meng

Chen²,

Yang³

et al. 2013

IJN

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Transdermal delivery of a pineal hormone: Melatonin via elastic liposomes

Cited by 96 publications

References 30 publications

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic

Enhanced transdermal bioavailability of testosterone propionate via surfactant-modified ethosomes

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