Transdermal Delivery Enhancement of Gel Containing Niosomes Loaded with Volvariella Volvacea Extract

Abstract

Our previous study demonstrated the potent in vitro collagen biosynthesis stimulating and antioxidant activities of Volvariella volvacea extract. This study was performed the loading of V. volvacea extract (VV) in niosomes (NV). The physicochemical characterization of the VV loaded niosomes and gel containing niosome of the extract (GNV) was studied. Rat skin transdermal absorption by Franz diffusion cells at 6 hours of NV, GNV was compared with V. Volvacea extract solution (SV). GNV and NV showed higher chemical stability of total phenolic contents than SV. NV exhibited negative zeta potential values with the mean size of 254±20.32 nm. Both GNV and NV retarded the cumulative amounts and fluxes of the total phenolic in the extract in the first hour of skin permeation, while enhanced the skin permeation at the 6 th hour in the experiment. GNV gave the highest percentages of the total phenolic content through rat skin to the receiving solution followed by NV and SV, respectively. This study has demonstrated the potential of gel containing niosomes of the V. volvacea extract appeared to be the suitable system for topical anti-aging application of V. volvacea extract because of the enhancement of chemical stability and rat skin transdermal absorption of V. volvacea extract.

Performance of Curcumin in Nanosized Carriers Niosomes and Ethosomes as Potential Anti-Inflammatory Delivery System for Topical Application

“…8 illustrates that CUR niosomes, as well as ethosomes, gives rise to the highest amount of CUR retained or deposited in SC (120.6±10.31 µg/cm 2 ) for niosomes and (80.5±5.80 µg/cm 2 ) for ethosome among other formulations. Such finding revealed that niosomes and ethosomes are suitable for the penetration into the skin and localized as a depot, while gel system of lipid vesicles can deliver more drug to receiving compartment which represents for blood vessels 42 . Therefore, it is worthy to note that, the gel containing niosomes and ethosomes loaded with CUR appeared to be the most appropriate system for a topical anti-inflammatory application.…”