Transdermal co-delivery of glucosamine sulfate and diacerein for the induction of chondroprotection in experimental osteoarthritis

Chattopadhyay, Helen; Auddy, Biswajit; Sur, Tapas Kumar; Gupta, Mradu; Datta, Sriparna

doi:10.1007/s13346-019-00701-7

Cited by 14 publications

(15 citation statements)

References 51 publications

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“…A study realized for Chattopadhyay et al [ 94 ] developed a nanoemulsion containing diacerein (DC) and glucosamine sulfate (GS) that was mixed with a hydrogel prepared with xanthan gum (XG) forming a nanoemulsion-laden hydrogel (NLH) for osteoarthritis treatment. The NEs average hydrodynamic diameter was 81.95 nm, and its PDI value was 0.285.…”

Section: Nanocarriers For Co-encapsulation In Topical Deliverymentioning

confidence: 99%

Co-Encapsulation of Drugs for Topical Application—A Review

et al. 2023

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Achieving the best possible outcome for the therapy is the main goal of a medicine. Therefore, nanocarriers and co-delivery strategies were invented to meet this need, as they can benefit many diseases. This approach was applied specifically for cancer treatment, with some success. However, these strategies may benefit many other clinical issues. Skin is the largest and most exposed organ of the human body, with physiological and psychological properties. Due to its exposition and importance, it is not difficult to understand how many skin diseases may impact on patients’ lives, representing an important burden for society. Thus, this review aims to summarize the state of the art in research concerning nanocarriers and co-delivery strategies for topical agents’ applications targeting skin diseases. The challenge for the medicine of the future is to deliver the drug with spatial and temporal control. Therefore, the co-encapsulation of drugs and the appropriate form of administration for them are so important and remain as unmet needs.

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Section: Nanocarriers For Co-encapsulation In Topical Deliverymentioning

confidence: 99%

Co-Encapsulation of Drugs for Topical Application—A Review

et al. 2023

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“…All animals were provided with food and water ad libitum and acclimatized for 10 days before treatment. 27,28 On Day 0, the right knee joint of each animal was made free from fur by using electric clippers. The animals were administered with 5% sodium-thiopentone for anesthesia.…”

Section: Animal Study Protocolmentioning

confidence: 99%

“…Thereafter the fabricated SEPS and its doses were investigated for efficacious regeneration of chondrocyte in experimental OA induced by monosodium iodoacetate in Wistar rat model. 27,28 2 | MATERIALS AND METHODS…”

Section: Introductionmentioning

confidence: 99%

Fabrication of N‐methyl morpholine‐N‐oxide modified bacterial exopolysaccharide as natural scaffold toward effective cartilage regeneration in monosodium iodoacetate induced experimental osteoarthritis

Sengupta,

Chattopadhyay,

Sur

et al. 2023

J of Applied Polymer Sci

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A non‐pathogenic strain of Ochrobactrum pseudintermedium C1 produces potent surface‐active exopolysaccharides which exhibits a porous scaffold‐like architecture. Such a property is quite prospective in facilitating housing of cells for in vivo tissue regeneration. This surfactant exopolysaccharide has been fabricated for augmenting such regenerative properties. Different vital parameters of the fabricated EPS like surface morphology, swelling behavior, in vitro degradation study, cytotoxicity and biocompatibility have been evaluated which helped postulate the applicative profile of this natural scaffold. Further, Ochrobactrum‐borne fabricated EPS, when applied as a scaffold in monosodium iodoacetate induced experimental osteoarthritis in Wistar rat model, helped significant chondrogenesis without leaving any residual amount of scaffold. The functional restoration of knee joints, assessment of chondroitin sulfate in damaged cartilage, diminution of stress induced indicators like reactive oxygen metabolite and histopathological findings quite appreciably favored the objectives. Moreover, a single high dose exhibited considerable efficacy compared to repetitive targeted administration of the scaffold at regular intervals. Thus, this novel biological macromolecule offers a green and cost‐effective alternative to various commercially available synthetic scaffolds that promote tissue regeneration.

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“…The subsequent study evaluated four pro‐inflammatory proteins that were not studied in the previous study. The results showed that the hydrogel formulation reduced serum concentration of tumor necrosis factor‐α (TNF‐α), C‐reactive protein (CRP), high mobility group box protein (HMGBP), and monocyte chemoattractant protein‐1 (MCP‐1; Chattopadhyay et al, 2020).…”

Section: Transdermal Formulations For Arthritic Injurymentioning

confidence: 99%

Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines

Shang

Younas

Zhang

2022

WIREs Nanomed Nanobiotechnol

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Arthritic injuries happen frequently during a lifetime due to accidents, sports, aging, diseases, etc. Such injuries can be cartilage/bone injuries, tendon injuries, ligament injuries, inflammation, pain, and/or synovitis. Oral and injective administration of therapeutics are typically used but cause many side effects. Transdermal administration is an alternative route for safe and efficient delivery. Transdermal formulations of non-steroidal anti-inflammatory drugs have been available on market for years and show promising efficacy in pain relieving, inflammation alleviation, infection control, and so on. Innovative transdermal patches, gels/films, and microneedles have also been widely explored as formulations to deliver therapeutics to combat arthritic injuries. However, transdermal formulations that halt disease progression and promote damage repair are translated slowly from lab bench to clinical applications. One major reason is that the skin barrier and synovial capsule barrier limit the efficacy of transdermal delivery. Recently, many nanocarriers, such as nanoparticles, nanolipids, nanoemulsions, nanocrystals, exosomes, etc., have been incorporated into transdermal formulations to advance drug delivery. The combined transdermal formulations show promising safety and efficacy.Therefore, this review will focus on stating the current development of nanomedicine-based transdermal formulations for the treatment of arthritic injuries. The advances, limitations, and future perspectives in this field will also be provided to inspire future studies and accelerate clinical translational studies.

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Transdermal co-delivery of glucosamine sulfate and diacerein for the induction of chondroprotection in experimental osteoarthritis

Cited by 14 publications

References 51 publications

Co-Encapsulation of Drugs for Topical Application—A Review

Co-Encapsulation of Drugs for Topical Application—A Review

Fabrication of N‐methyl morpholine‐N‐oxide modified bacterial exopolysaccharide as natural scaffold toward effective cartilage regeneration in monosodium iodoacetate induced experimental osteoarthritis

Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines

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