Transdermal clonidine for ameliorating tamoxifen-induced hot flashes.

Goldberg, Richard M.; Loprinzi, Charles L.; O’Fallon, Judith R.; Veeder, Michael H.; Miser, Angela W.; Mailliard, James A.; Michalak, John C.; Dose, Ann Marie; Rowland, Kendrith M.; Burnham, Nora

doi:10.1200/jco.1994.12.1.155

Cited by 264 publications

(107 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Soy based diets are often recommended [2], but the effects of phytoestrogens on breast cancer are unknown [19]. Progesterone, clonidin and selective serotonin reuptake inhibitors have been shown to reduce hot flashes but may have significant side-effects and are not widely used in clinical settings [4,20]. Hot flashes are reported to be the most prominent side-effect of Tamoxifen medication [4,21,22].…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial

Hervik

Mjåland

2008

Breast Cancer Res Treat

112

119

View full text Add to dashboard Cite

Acupuncture has been used to treat the problem of hot flashes in healthy postmenopausal women. The object of this study was to investigate the efficacy of acupuncture in women with breast cancer suffering from hot flashes as a result of anti-oestrogen medication. In a prospective, controlled trial, 59 women suffering from hot flashes following breast cancer surgery and adjuvant oestrogen-antagonist treatment (Tamoxifen) were randomized to either 10 weeks of traditional Chinese acupuncture or sham acupuncture (SA). Mean number of hot flashes at day and night were recorded prior to treatment, during the treatment period as well as during the 12 weeks following treatment. A validated health score (Kupperman index) was conducted at baseline, at the end of the treatment period and at 12 weeks following treatment. During the treatment period mean number of hot flashes at day and night was significantly reduced by 50 and almost 60%, respectively from baseline in the acupuncture group, and was further reduced by 30% both at day and night during the next 12 weeks. In the sham acupuncture group a significant reduction of 25% in hot flashes at day was seen during treatment, but was reversed during the following 12 weeks. No reduction was seen in hot flashes at night. Kupperman index was reduced by 44% from baseline to the end of the treatment period in the acupuncture group, and largely maintained 12 weeks after treatment ended. No corresponding changes were seen in the sham acupuncture group. Acupuncture seems to provide effective relief from hot flashes both day and night in women operated for breast cancer, treated with Tamoxifen. This treatment effect seems to coincide with a general health improvement measured with the validated Kupperman index.

show abstract

Section: Discussionmentioning

confidence: 99%

Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial

Hervik

Mjåland

2008

Breast Cancer Res Treat

112

119

View full text Add to dashboard Cite

show abstract

“…Clonidine has been shown to have some activity in reducing hot flashes in breast cancer patients [17,18]. However, in clinical practice, its use is limited by its side effect profile including dry mouth, constipation, and drowsiness.…”

Section: Nonhormonalmentioning

confidence: 99%

A practical guide to the management of menopausal symptoms in breast cancer patients

Gainford

Simmons

Nguyen

et al. 2005

Support Care Cancer

View full text Add to dashboard Cite

Breast cancer is the most frequently diagnosed cancer in Canadian women. As a result of increased screening and improved treatment, more women are becoming long-term breast cancer survivors. However, due to either their treatment or prolonged survival, many of these women now have to face the consequences of premature menopause and prolonged estrogen deprivation. Hormone replacement therapy/estrogen replacement therapy (HRT/ERT) has, in the past, been recommended to healthy women at menopause not only for relief of short-term menopausal changes, particularly hot flashes, but also for its benefits on bone density, fracture reduction, and genitourinary symptoms. Recent studies have demonstrated that not only is HRT associated with an increased risk of developing breast cancer, but it also has been shown to increase the risk of recurrence in those with a breast cancer history. Until the safety of HRT/ERT in breast cancer patients can be more fully clarified, it would be wise to develop alternative strategies for the management of menopausal symptoms in these patients. This paper will discuss nonestrogen-based therapies for hot flashes, osteoporosis, and genitourinary symptoms, with emphasis on efficacy and safety in breast cancer survivors.

show abstract

“…Hot flash scores were calculated by multiplying the number of hot flashes with their severity [11,17,18].…”

Section: Daily Diary On Hot Flashesmentioning

confidence: 99%

“…In women with a history of breast cancer hormonal therapy should be avoided, because of possible stimulating effects on tumor growth [8]. Drugs that do not interfere with steroid receptors, among which clonidine and venlafaxine, are efficacious in reducing hot flashes in breast cancer patients in randomized placebo-controlled trials [10][11][12].…”

Section: Introductionmentioning

confidence: 98%

“…Clonidine is a centrally acting a-adrenergic agonist, that alleviates hot flashes at an oral dose of 0.05 mg twice daily (bid) [11,13,14]. Venlafaxine, a combined serotonin and norepinephrine re-uptake inhibitor (SNRI), is effective for the reduction of hot flashes in a dose of 75 mg once daily (od) as extended-release formulation [12,15,16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Venlafaxine versus clonidine for the treatment of hot flashes in breast cancer patients: a double-blind, randomized cross-over study

Buijs

Mom

Willemse

et al. 2008

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

Transdermal clonidine for ameliorating tamoxifen-induced hot flashes.

Abstract: Better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.

Cited by 264 publications

References 6 publications

Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial

Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial

A practical guide to the management of menopausal symptoms in breast cancer patients

Venlafaxine versus clonidine for the treatment of hot flashes in breast cancer patients: a double-blind, randomized cross-over study

Contact Info

Product

Resources

About