Transcutaneous Vagus Nerve Stimulation: an Alternative Treatment of Chronic Migraine—a Systematic Review

Carvalho, Ana Cláudia de; Marques, Aeska Lanary Cristino; Ferreira, Laís; Brito, Francisco; Baptista, Abrahão Fontes; Silva, Marcelo Lourenço da; Silva, Josie Resende Torres da

doi:10.1007/s42399-022-01268-0

Cited by 2 publications

(1 citation statement)

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“…The study also mentions an interesting trial performed in 2015 by the author himself wherein two different frequencies of VNS- 1 Hz and 25 Hz transauricular VNS were used and the 1 Hz group had more significant reduction in headache days per month and greater numbers of responders than the 25 Hz group. These parameters also find mention in the systematic review by Carvalho et al [14 ▪ ], in which a frequency of 30 Hz transauricular VNS was also noted to be used for headache management. Both cervical and transauricular VNS find a favorable mention among various neuromodulatory techniques in a review by Tiwari et al [15 ▪ ].…”

Section: Evidence From Systematic Reviews and Meta-analysesmentioning

confidence: 69%

Vagal nerve stimulation for headache

Venkatakrishnan,

Thomas

2023

Current Opinion in Neurology

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Purpose of review Vagal nerve stimulation (VNS) is emerging as a probable therapeutic option for headache. Several questions remain on the mechanism of action, device parameters, efficacy, duration of treatment and long-term safety. This review aims at describing findings of recent literature pertaining to VNS for headache, to put these findings into the perspective of our current fund of knowledge and future scope of work on the topic. Recent findings Several studies on functional magnetic resonance imaging patterns following VNS in patients with headache have been published, revealing potential biomarkers of headache and possible treatment effects. A study on post-COVID-19 headache and its management with noninvasive cervical VNS adds to the body of original studies. Meta-analyses and systematic reviews outlining previous work have been published. The collection of these studies adds some data to mechanisms of VNS without adding much insight to differential effects of sub-types of VNS and possible device settings that could prove to be beneficial for headache management. Summary Well designed studies are needed to identify mechanisms of action, elicit differential effects of various stimulation parameters, and to demonstrate long-term therapeutic effects and safety of VNS in headache.

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Section: Evidence From Systematic Reviews and Meta-analysesmentioning

confidence: 69%