Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction: A Pilot Study for an International Multicenter Randomized Controlled Trial

Tornic, Jure; Liechti, Martina D.; Stalder, Stephanie A; Birkhäuser, Veronika; Lely, Stéphanie van der; Leitner, Lorenz; Mehnert, Ulrich; Kessler, Thomas M.

doi:10.1016/j.euf.2019.11.008

Cited by 11 publications

(17 citation statements)

References 17 publications

(28 reference statements)

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“…Studies were also identified in the literature (n=13) in which patients with PD were included in grouped cohorts of "neurogenic overactive bladder", containing individuals with other conditions such as multiple sclerosis, Alzheimer's and spinal cord injury. Seven described tibial nerve stimulation interventions (four PTNS, [25][26][27][28] four TTNS [29][30][31][32] ) and five SNM. [33][34][35][36][37] These either provided data on the proportion of participants with PD or did not provide a breakdown of the cohort by diagnosis.…”

Section: Search Resultsmentioning

confidence: 99%

Neuromodulation for Storage Lower Urinary Tract Symptoms in Parkinson Disease: A Systematic Review

Smith

Tenison

Hashim

et al. 2022

Neuromodulation: Technology at the Neural Interface

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Section: Search Resultsmentioning

confidence: 99%

Neuromodulation for Storage Lower Urinary Tract Symptoms in Parkinson Disease: A Systematic Review

Smith

Tenison

Hashim

et al. 2022

Neuromodulation: Technology at the Neural Interface

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“…Electrical parameters such as the stimulation frequency, intensity, number, and duration of stimulation sessions were highly variable among studies, which reinforces that there was not a universally established regimen for it. Generally, the frequency of TENS ranges from 2 to 75 Hz (16,17,(19)(20)(21)(37)(38)(39). Electrical stimulation with low frequency (2-50 HZ) evoked bladder contraction, resulting in increasing voiding efficiency (39).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effect of Early Post-operative Transcutaneous Electrical Stimulation on Voiding Function After Radical Hysterectomy: A Multicenter, Randomized, Controlled Trial

Gao

Wang

et al. 2021

Front. Med.

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Introduction: Post-radical-hysterectomy (RH) patients suffer from a series of problems resulting from neurovascular injury, such as bladder dysfunction, which reduce their quality of life. We have designed this study to evaluate the efficacy of transcutaneous electrical stimulation (TENS) on patient rehabilitation after RH for early cervical cancer.Materials and methods: A total of 97 patients were enrolled in a randomized-controlled trial (from January 2015 to December 2019) involving 7 medical centers nationwide. Patients were assigned to either the intervention group (n = 46), or the control group (n = 51). TENS was given to patients in the intervention group from the 7th day after surgery for a total of 14–21 days. The control group received no TENS. Primary outcomes were measured for residual urine volume and recovery of urination function. Secondary outcomes were measures for urodynamics (UDS), pelvic floor electromyography function examination (PFEmF), and quality of life (QoL).Results: Residual urine volume and improvement in the rate of urination were found to show no significant differences on the 14th, 21st, and 28th days after surgery. The maximum flow rate (Qmax) in the intervention group was significantly higher than that in the control group on the 28th day, but there were no significant differences in average flow rate, voiding time, time to Qmax, muscle fiber strength, muscle fiber fatigue, and the abnormal rate of A3 reflection on the 28th day and the 3rd mo., as well as in the QoL at 3rd mo., 6th mo., and 12th mo. after surgery.Conclusion: Our study showed no sufficient evidence to prove that TENS under the trialed parameters could improve the subject's voiding function, PFEmF, and QOL after RH. This has provided valuable data for rehabilitation after RH.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT02492542.

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“…The biggest difference between PTNS and TTNS is that the latter replaces the needle electrode with two surface adhesive electrodes. TTNS, a noninvasive treatment with low cost and minimal side effects, has been used clinically, 11,12 while TTNS devices used today are not wearable and the duration of each stimulation treatment is also limited.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of a smartphone‐controlled wearable transcutaneous tibial nerve stimulation device on bladder reflexes in anesthetized cats

Liang

Liu

Wan

et al. 2022

Neurourology and Urodynamics

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Objectives: To explore the inhibitory effects of a novel, smartphonecontrolled, and wearable tibial nerve stimulation device on nonnociceptive and nociceptive bladder reflexes in anesthetized cats and to compare the stimulus results of two current waveforms outputted by this new stimulator.Materials and Methods: A novel, intelligent tibial nerve stimulator was put on the ankles of 14 cats and controlled by a mobile application. Cystometrograms (CMGs) were performed repeatedly by infusing 0.9% normal saline (NS) and 0.5% acetic acid (AA) through a urethral catheter. Inhibitory effects were explored by measuring the bladder capacity (BC) in two areas: (1) on nonnociceptive bladder reflex (infused with NS) and on nociceptive bladder reflex (filled with AA to induce overactive bladder[OAB] model); and (2) under the stimulation of two different current waveforms (waveforms A and B). Results: In Group 1, the BC of AA-induced OAB (41.48 ± 8.40%) was significantly different compared with the capacity of a NS-infused bladder (104.89 ± 1.32%, p < 0.05). Both NS-filled (151.35 ± 5.71%, p < 0.05) and AA-instilled (71.41 ± 9.34%, p < 0.05) bladder volumes significantly increased after tibial nerve stimulation (TNS). In Group 2, the BC increased to 166.18 ± 15.17% (p = 0.026) and 127.64 ± 13.00% (p = 0.239), respectively, after TNS with waveforms A and B current. Conclusions: Results revealed that this novel, smartphone-based, wearable, and wireless tibial nerve stimulation system could inhibit the micturition reflex on physiological condition, serving as a potential option for OAB treatment. In addition, the waveforms of stimulation current had an important influence on the effects of TNS.

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Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction: A Pilot Study for an International Multicenter Randomized Controlled Trial

Cited by 11 publications

References 17 publications

Neuromodulation for Storage Lower Urinary Tract Symptoms in Parkinson Disease: A Systematic Review

Neuromodulation for Storage Lower Urinary Tract Symptoms in Parkinson Disease: A Systematic Review

Long-Term Effect of Early Post-operative Transcutaneous Electrical Stimulation on Voiding Function After Radical Hysterectomy: A Multicenter, Randomized, Controlled Trial

Inhibitory effects of a smartphone‐controlled wearable transcutaneous tibial nerve stimulation device on bladder reflexes in anesthetized cats

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