Transcutaneous Electrical Nerve Stimulation in Nerve Regeneration: A Systematic Review of In Vivo Animal Model Studies

Alarcón, Josefa; Chuhuaicura, Priscila; Sluka, K.; Fazan, V.P.; Godoy, Karina; Fuentes, Ramón; Días, Fernando José

doi:10.1016/j.neurom.2021.12.009

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…The persistent positive remission of sensory and motor disorders within 3 months after the end of treatment indicates restoration in the structure of the nerve, as well as the development of persistent compensatory re-innervation changes in the affected muscles. In the literature, the prolonged effect of TENS has been demonstrated in many works [ 70 , 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Efficiency of Direct Transcutaneous Electroneurostimulation of the Median Nerve in the Regression of Residual Neurological Symptoms after Carpal Tunnel Decompression Surgery

Al-Zamil,

Minenko,

Kulikova

et al. 2023

Biomedicines

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Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy. CTS therapy includes wrist immobilization, kinesiotherapy, non-steroidal anti-inflammatory drugs, carpal tunnel steroid injection, acupuncture, and physical therapy. Carpal tunnel decompression surgery (CTDS) is recommended after failure of conservative therapy. In many cases, neurological disorders continue despite CTDS. The aim of this study was to investigate the efficiency of direct transcutaneous electroneurostimulation (TENS) of the median nerve in the regression of residual neurological symptoms after CTDS. Material and Methods: 60 patients aged 28–62 years with persisting sensory and motor disorders after CTDS were studied; 15 patients received sham stimulation with a duration 30 min.; 15 patients received high-frequency low-amplitude TENS (HF TENS) with a duration 30 min; 15 patients received low-frequency high-amplitude TENS (LF TENS) with a duration 30 min; and 15 patients received a co-administration of HF TENS (with a duration of15 min) and LF TENS (with a duration of 15 min). Results: Our research showed that TENS significantly decreased the pain syndrome, sensory disorders, and motor deficits in the patients after CTDS. Predominantly, negative and positive sensory symptoms and the pain syndrome improved after the HF TENS course. Motor deficits, reduction of fine motor skill performance, electromyography changes, and affective responses to chronic pain syndrome regressed significantly after the LF TENS course. Co-administration of HF TENS and LF TENS was significantly more effective than use of sham stimulation, HF TENS, or LF TENS in patients with residual neurological symptoms after CTDS.

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Section: Discussionmentioning

confidence: 99%

Efficiency of Direct Transcutaneous Electroneurostimulation of the Median Nerve in the Regression of Residual Neurological Symptoms after Carpal Tunnel Decompression Surgery

Al-Zamil,

Minenko,

Kulikova

et al. 2023

Biomedicines

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“…However, there may be a role for this approach after muscle reinnervation has occurred to increase muscle strength as an adjunct to sensory re-education. Low-frequency repetitive nerve stimulation is a more promising technique and has been shown to stimulate rapid motor reinnervation postoperatively [76–78,79 ▪ ,80,81 ▪ ]. Optimization of stimulation settings and evaluation of this technique in specific clinical scenarios is still required [76,82].…”

Section: Managementmentioning

confidence: 99%

Traumatic peripheral nerve injuries: diagnosis and management

Barnes

Miller²,

Simon

2022

Current Opinion in Neurology

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Purpose of reviewTo review advances in the diagnostic evaluation and management of traumatic peripheral nerve injuries.Recent findingsSerial multimodal assessment of peripheral nerve injuries facilitates assessment of spontaneous axonal regeneration and selection of appropriate patients for early surgical intervention. Novel surgical and rehabilitative approaches have been developed to complement established strategies, particularly in the area of nerve grafting, targeted rehabilitation strategies and interventions to promote nerve regeneration. However, several management challenges remain, including incomplete reinnervation, traumatic neuroma development, maladaptive central remodeling and management of fatigue, which compromise functional recovery.SummaryInnovative approaches to the assessment and treatment of peripheral nerve injuries hold promise in improving the degree of functional recovery; however, this remains a complex and evolving area.

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“…TENS was originally intended for the treatment of pain [ 17 ]. Gradually, the effectiveness of TENS in accelerating regenerative processes and reducing neurological deficits has been proven in many clinical and experimental studies [ 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…The motor recovery effect of TENS has been studied in numerous experimental and clinical studies. Many authors believe that the use of TENS leads not only to accelerated functional motor recovery but also to an enhancement in the axon quantity and the diameter of the regenerated axons [ 18 ]. At the same time, low-frequency high-amplitude TENS (LF TENS), rather than high-frequency low-amplitude TENS (HF TENS), leads to an increase in fiber diameter and thickening of the myelin sheath [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Functional Recovery and Regenerative Effects of Direct Transcutaneous Electrical Nerve Stimulation in Treatment of Post-COVID-19 Guillain–Barré and Acute Transverse Myelitis Overlap Syndrome: A Clinical Case

Al-Zamil,

Kulikova,

Minenko

et al. 2024

JFMK

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Transcutaneous electrical nerve stimulation (TENS) has proven effective in treating pain in many experimental and clinical studies. In addition to the analgesic effect, direct TENS of peripheral nerves had anti-inflammatory and regenerative effects in the treatment of distal polyneuropathy and spinal cord injury. This work demonstrates the experience of using direct TENS in the treatment of a 52-year-old patient with post-COVID-19 Guillain–Barré (GBS) and acute transverse myelitis (ATM) overlap syndrome. Direct TENS of peripheral nerves showed high efficiency in enhancing the therapeutic effect of combined plasma exchange and pharmacotherapy by 89.5% with a significant reduction in neuropathic pain, motor and sensory deficits, bladder and bowel disorders and regression of neurophysiological changes. We suggest that direct TENS of peripheral nerves can be a promising option for combined therapy of GBS and ATM overlap syndrome and other diseases with the simultaneous development of distal polyneuropathy and spinal cord injury. Further trial studies are required.

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Transcutaneous Electrical Nerve Stimulation in Nerve Regeneration: A Systematic Review of In Vivo Animal Model Studies

Cited by 7 publications

References 40 publications

Efficiency of Direct Transcutaneous Electroneurostimulation of the Median Nerve in the Regression of Residual Neurological Symptoms after Carpal Tunnel Decompression Surgery

Efficiency of Direct Transcutaneous Electroneurostimulation of the Median Nerve in the Regression of Residual Neurological Symptoms after Carpal Tunnel Decompression Surgery

Traumatic peripheral nerve injuries: diagnosis and management

Functional Recovery and Regenerative Effects of Direct Transcutaneous Electrical Nerve Stimulation in Treatment of Post-COVID-19 Guillain–Barré and Acute Transverse Myelitis Overlap Syndrome: A Clinical Case

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