Transcutaneous electrical acupoint stimulation for high-normal blood pressure: study protocol for a randomized controlled pilot trial

Wang, Yu; Shi, Guang‐Xia; Tian, Zhong-Xue; Liu, Junhong; Qi, You-Sheng; Tu, Jian‐Feng; Yang, Jing‐Wen; Liu, Cun‐Zhi

doi:10.1186/s13063-021-05039-5

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…It plays an important role in the treatment of neurological diseases by regulating the related pathways to repair the damage. It has a good effect on the complications of neuropathic pain, neurogenic bladder, and digestive tract disorders after SCI [5][6][7]. Basic studies have found that EA stimulation of Dazhui and Mingmen acupoints can inhibit the expression of G1uR1 in SCI rats, reduce the excitotoxicity of glutamate, and promote the recovery of neuronal and hindlimb motor functions [8].…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis on the Effects of Electric Acupuncture on Neural Functional Recovery and Related Pathways of Rats after Spinal Cord Injury

Lai¹,

Liu

Liu³

2022

BioMed Research International

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Background. Spinal cord injury (SCI) is a type of damage to the central nervous system (CNS) caused by various factors. The secondary injury of SCI is more complicated. Studies have found that electroacupuncture can help the recovery of nerve function during spinal cord injury. Therefore, this study explored the efficacy of electroacupuncture on complications after spinal cord injury through meta-analysis. Methods. Relevant literatures published from January 2010 to March 2022 were searched with “Electric acupuncture, Spinal cord injury, Neural functional recovery, Spinal cord injury in rats, Neuronal Signaling” as search words. The risk of bias of included references was analyzed and assessed using RevMan 5.3 software and Stata software. Heterogeneity between studies was assessed using the Q -test and heterogeneity ( I 2 ). Results. There was no heterogeneity among the study groups. The comparison on the therapeutic effects of electroacupuncture and conventional therapy suggested that electroacupuncture was more effective for nerve recovery after spinal cord injury than conventional therapy. It can better improve the recovery of motor function after spinal cord injury in rats. On the other hand, SCI+EA had a good inhibitory effect on the expression of RhoA protein signal in rats and had a positive effect on the signal pathway. Discussion. The results of meta-analysis confirmed that electroacupuncture was more effective than conventional therapy in inhibiting pathways.

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Section: Introductionmentioning

confidence: 99%

Meta-Analysis on the Effects of Electric Acupuncture on Neural Functional Recovery and Related Pathways of Rats after Spinal Cord Injury

Lai¹,

Liu

Liu³

2022

BioMed Research International

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“…A recent study showed that 18 sessions of electroacupuncture during a 6-weeks time period caused an 8-mmHg reduction in SBP for patients with mild hypertension, and the effect on SBP reduction lasted for another 6 week after the acupuncture treatment was terminated. 29 In this trial, we found that TEAS combined with lifestyle modification lowered the mean SBP by 5 mmHg and lowered the mean DBP by 3 mmHg. One possible reason for the discrepancies may be the differences in the therapeutic schedule.…”

Section: Discussionmentioning

confidence: 70%

“…In addition, the study was registered in the Chinese Clinical Trial Registry (ChiCTR 1900024982) on August 6, 2019. Details of the trial's design and analysis plan have been previously published 29 …”

Section: Methodsmentioning

confidence: 99%

Home‐based transcutaneous electrical acupoint stimulation for high‐normal blood pressure: A randomized controlled trial

Wang

Yang

Liu

et al. 2022

J of Clinical Hypertension

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The authors investigated the effectiveness of home-based transcutaneous electrical acupoint stimulation (TEAS) combined with lifestyle modification on blood pressure (BP) control and explored the feasibility of the trial design in this prospective, randomized controlled trial. The authors recruited individuals with high-normal BP who had a systolic blood pressure (SBP) of 120-139 mm Hg and a diastolic blood pressure (DBP) of 80-89 mm Hg, or both. Participants were randomly assigned to receive either lifestyle modification combined with TEAS four times weekly for 12 weeks at home (intervention group) or solely lifestyle modification (control group). The primary outcome was the change in mean SBP at week 12 from the baseline measurement. A total of 60 participants were randomized in a 1:1 ratio, and an intention-to-treat analysis was performed on all of the outcomes. The mean difference in the change in SBP for the intervention group (compared to the control) at week 12 was −3.85 mm Hg (95% CI: −7.58 to −.12; p = .043); for the DBP, the change was −2.27 mm Hg (95% CI: −5.76 to 1.23; p = .199). There was no difference in the proportion of progression to hypertension, quality of life, body mass index (BMI) or waist circumference. In addition, two participants reported TEAS-related adverse events. The authors found a reduction in SBP control in the pragmatic, home-based intervention by using TEAS combined with lifestyle modification in adults with high-normal BP.

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“…The instrument has ten levels of stimulus intensities, and patients asked to increase the stimulus intensity until local, rhythmic contractions of the muscle are obtained without producing pain. According to the previous studies,16 19 21 22 bilateral Hegu (LI4), Quchi (LI11), Zusanli (ST36) and Taichong (LR3) will be used in our trial. On the first day, the electrodes will be placed at the ipsilateral LI4 and LI11, and the appropriate stimulus intensity will last for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Smart phone-based transcutaneous electrical acupoint stimulation as adjunctive therapy for hypertension (STAT-H trial): protocol for a cluster randomised controlled trial

Kang

Wang

et al. 2022

BMJ Open

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IntroductionHypertension is a common risk factor for cardiovascular disease. Transcutaneous electrical acupoint stimulation (TEAS) may be effective for hypertension, but the evidence remains limited. The aim of this study is to evaluate the effectiveness and safety of the smart phone-based TEAS as adjunctive therapy for hypertension.Methods and analysisThis study is a 52-week cluster randomised controlled trial with 1600 hypertension patients in 32 community health service centres. Patients who meet the inclusion criteria will be randomised into usual care group or TEAS group in a 1:1 ratio. All patients will be provided with usual care as recommended by the guidelines. In addition to this, patients in the TEAS group will receive non-invasive acupoint electrical stimulation for 30 min at home, 4 times weekly for 12 weeks. The primary outcome will be the mean difference in the changes in office systolic blood pressure from baseline to 12 weeks between TEAS and usual care groups. Secondary outcomes will include the change of mean diastolic blood pressure, proportion of patients with controlled blood pressure (blood pressure <140/90 mm Hg), proportion of patients taking antihypertensive drugs, change in number of antihypertensive drugs and changes in 12-item Short-Form. Tertiary outcomes will include change in body mass index, change in waist circumference, physical activity and medication adherence. Safety outcomes will be any serious adverse events and clinical events.Ethics and disseminationThis study has been approved by ethics committee of Beijing University of Chinese Medicine (No. 2020BZHYLL0104). Written informed consent will be obtained from all patients before randomisation. Trial results will be disseminated in peer-reviewed publications.Trial registration numberChiCTR2000039400.

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Transcutaneous electrical acupoint stimulation for high-normal blood pressure: study protocol for a randomized controlled pilot trial

Cited by 8 publications

References 35 publications

Meta-Analysis on the Effects of Electric Acupuncture on Neural Functional Recovery and Related Pathways of Rats after Spinal Cord Injury

Meta-Analysis on the Effects of Electric Acupuncture on Neural Functional Recovery and Related Pathways of Rats after Spinal Cord Injury

Home‐based transcutaneous electrical acupoint stimulation for high‐normal blood pressure: A randomized controlled trial

Smart phone-based transcutaneous electrical acupoint stimulation as adjunctive therapy for hypertension (STAT-H trial): protocol for a cluster randomised controlled trial

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