Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity

Pund, Swati; Pawar, Sagar; Gangurde, S A; Divate, Deepali

doi:10.1016/j.ijpharm.2015.04.015

Cited by 59 publications

(34 citation statements)

References 31 publications

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“…Capmul is a substance used for various purposes in research on various types of formulations. However, in studies on skin formulations, Capmul was rejected during carrier optimization [ 52 ] or its effect on human skin cells was not determined [ 53 ]. Capmul ® MCM at concentrations ≥ 0.625% ( w/v ) damaged the monolayer of the Caco-2 cell line in studies by Keemink and Bergstrom [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

et al. 2020

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The developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)—isotropic mixtures of oils, surfactants, solvents and co-solvents or surfactants—are attracting interest in the cosmeceutical field. As part of this study, SEDDS systems containing vitamin C or vitamin E and curcumin were developed, whereby the bioavailability of the active compounds increased by enhancing their permeability to deeper layers of the skin. A composition consisting of 50% surfactin from Bacillus subtilis, 30% Transcutol and 20% oil phase was designed to encapsulate the active substances, i.e., vitamin C or vitamin E and curcumin, contained in the oil phase. The developed carriers were characterized by average particle sizes of 69–183 nm. The formulations with the vitamins were found to be physically and chemically stable for 6 months. Transdermal tests were carried out, showing that the carriers enable the transport of active substances deep into the skin, stopping at the dermis border. The formulations with vitamin C and vitamin E reduced the discoloration, the vascular lesions, and the depth of the wrinkles on the tested skin, which can be useful in cosmetics in the treatment of problem skin, including capillary and sensitive skin.

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Section: Resultsmentioning

confidence: 99%

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

et al. 2020

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“…The emulsified gel has proven to be stable and a better vehicle for hydrophobic or poorly water-soluble drugs such as calcipotriol [ 109 , 165 ], cyclosporine [ 167 ], leflunomide [ 171 ], and betamethasone dipropionate [ 174 ]. Similarly to hydrogels, emulgels can be a carrier of plant extracts with a potential therapeutic effect [ 172 ] or, similar to oleogels, they can contain fish oil, which can additionally act as a penetration enhancer and have an anti-inflammatory effect [ 175 ].…”

Section: Polymeric Gels and Their Propertiesmentioning

confidence: 99%

Polymeric Gels and Their Application in the Treatment of Psoriasis Vulgaris: A Review

Kulawik‐Pióro

Miastkowska

2021

IJMS

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Psoriasis is a chronic skin disease, and it is especially characterized by the occurrence of red, itchy, and scaly eruptions on the skin. The quality of life of patients with psoriasis is decreased because this disease remains incurable, despite the rapid progress of therapeutic methods and the introduction of many innovative antipsoriatic drugs. Moreover, many patients with psoriasis are dissatisfied with their current treatment methods and the form with which the drug is applied. The patients complain about skin irritation, clothing stains, unpleasant smell, or excessive viscosity of the preparation. The causes of these issues should be linked with little effectiveness of the therapy caused by low permeation of the drug into the skin, as well as patients’ disobeying doctors’ recommendations, e.g., concerning regular application of the preparation. Both of these factors are closely related to the physicochemical form of the preparation and its rheological and mechanical properties. To improve the quality of patients’ lives, it is important to gain knowledge about the specific form of the drug and its effect on the safety and efficacy of a therapy as well as the patients’ comfort during application. Therefore, we present a literature review and a detailed analysis of the composition, rheological properties, and mechanical properties of polymeric gels as an alternative to viscous and greasy ointments. We discuss the following polymeric gels: hydrogels, oleogels, emulgels, and bigels. In our opinion, they have many characteristics (i.e., safety, effectiveness, desired durability, acceptance by patients), which can contribute to the development of an effective and, at the same time comfortable, method of local treatment of psoriasis for patients.

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“…The ex-vivo permeation study showed a significant enhancement in the flux of 5.65 times with nanoemulgel formulation compared to ordinary gel, permeability coefficient increased from 5.93 to 33.48 cm -2 min -1 and drug deposition in the skin from 222.7 to 1287.2 μg. 91 Bifonazole-loaded self-emulsifying system was formulated by Alhakamy and Hosny utilizing Peceol ® , Kolliphore ® EL and Plurol Oleique ® 497 for the topical delivery of this antifungal agent, the nano size of the formula enhanced drug antifungal activity and its permeability by 1.85 and 2.179 folds compared to aqueous suspension, due to the tendency of Kolliphore ® EL toward the cellular membrane and the formation of micelles by Plurol Oleique ® 497, thereby, extracting the lipids from the skin and enabling greater penetration of bifonazole across skin deeper layer proving that this system is an efficient vehicle for transdermal delivery. 92 Bio-molecules delivery Bio-molecules (lipids, proteins, genes, and polysaccharides) have earned great attention as modern therapeutics due to their high selectivity, specificity, and low-toxic effects.…”

Section: Mucus Permeation Enhancermentioning

confidence: 99%

Formulation and Applications of Lipid-Based Nanovehicles: Spotlight on Self-emulsifying Systems

Mehanna

Mneimneh

2020

Adv Pharm Bull

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Introduction Synthesizing new drugs alone is not sufficient to establish advancement in drug therapy. The conventional drug delivery systems are destined to failure, due to many factors, mainly low drug solubility, poor absorption, enzymatic degradation, rapid metabolism, cellular efflux and variability in plasma concentration. 1 Incorporation of lipids in drug delivery has been a trend in the past decades. Lipid-based carriers are composed of phospholipids, cholesterol, cholesterol esters and triglycerides among others. 2 The physiochemical diversity of lipids, their biocompatibility and their resemblance to body tissue constituents offer a promising system for poorly water-soluble and lipophilic drugs. 3 Lipid carriers (LCs) provide several advantages that enable it to be an ideal vehicle for drug delivery. Namely; it can be manipulated according to product requirements whether its disease conditions, route of administration, stability, toxicity or efficacy. Besides, lipid-based formulations (LBFs) can provide a controlled release delivery based on their biocompatibility with body tissue after administration, it's not susceptible to erosion phenomena, the feasibility of scaling up, 4 moreover, it provides enhanced drug loading, ability to carry both lipophilic and hydrophilic drugs and stability. However, LCs face certain limitations such as, lipid crystallization that leads to polymorphism with different drug loading capacity, different shapes, and various kinetic distributions. High-pressure homogenization technique is most commonly used and it might cause drug degradation in high molecular weight compounds. Lipid-based carriers are recognized as safe and efficient hence they have been used as alluring candidates for pharmaceutical, as well as vaccines, diagnostics, and nutraceutical formulations. Therefore, lipid-based drug delivery (LBDD) systems have gained much importance in recent years due to their ability to improve the solubility and bioavailability of drugs with poor water solubility. Self-emulsifying drug delivery systems which belongs to LBFs are efficient, sophisticated, and more patient compliant formulation method for poorly water soluble drugs. It may enhance drug solubility, dissolution behavior in the GIT, gut permeability and thus may increase the absorption of the poorly water soluble model drug. This paper illustrates different types of LBFs to be precise, emulsions, vesicular systems, and lipid particulate systems and their subcategories, focusing on self-nanoemulsifying systems and their applications in the pharmaceutical field. Materials and Methods In this review, related articles and research papers from different reliable researchers and database such as Elsevier, Springer and MDPI were collected and discussed. The search was constructed based on the following keywords: lipid-based drug delivery, self-nanoemulsifying system, lipid vesicular systems.

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Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity

Cited by 59 publications

References 31 publications

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

Polymeric Gels and Their Application in the Treatment of Psoriasis Vulgaris: A Review

Formulation and Applications of Lipid-Based Nanovehicles: Spotlight on Self-emulsifying Systems

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