Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns

Okwundu, Charles I; Uthman, Olalekan A.; Suresh, Gautham; Smith, Johan; Wiysonge, Charles Shey; Bhutani, Vinod K.

doi:10.1002/14651858.cd012660

Cited by 10 publications

(13 citation statements)

References 32 publications

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“…However, this method is used primarily in research labs due to its technical complexity which renders it unfeasible for clinical use [24], [25]. Clinically, the TSB is usually assessed by the diazo reaction method or direct spectrophotometry [5], [23], [26], [27]. Since these methods were most prevalent around the world, they were taken as reference standards for this study, according to the method available and normally used in each hospital laboratory (Lab) (eTable 1 in the Supplement).…”

Section: Methodsmentioning

confidence: 99%

Diagnostic Performance Analysis of the Point-of-Care Bilistick System in Identifying Severe Neonatal Hyperbilirubinemia by a Multi-Country Approach

et al. 2018

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Importance The real prevalence and clinical burden of severe neonatal jaundice are undefined due to difficulties in measuring total serum bilirubin (TSB) outside secondary and tertiary clinical centers. Objective To assess the diagnostic performance of the point-of care Bilistick System (BS) in identifying neonatal jaundice patients requiring treatment. Design Between April 2015 and November 2016, 1911 neonates, were recruited to participate in the study. Blood samples were simultaneously collected for the TSB determination by BS and by hospital laboratory (Lab). Data were collected and sent to the Bilimetrix headquarter in Trieste where statistical analysis was performed. Newborns with neonatal jaundice were treated with phototherapy according to each center's guidelines. Setting 17 hospitals from Nigeria, Egypt, Indonesia, and Viet Nam. Participants 1911 newborns were included, of which 1458 (76·3%) fulfilled the inclusion criteria. Results TSB level measured by BS agreed (p < .0001) with the lab result in all four countries. The diagnostic performance of BS showed a positive predictive value (PPV) of 92·5% and a negative predictive value (NPV) of 92·8%. Conclusions and Relevance BS is a reliable system to detect neonatal jaundice over a wide range of bilirubin levels. Since Bilistick is a point-of-care test, its use may provide appropriate and timely identification of jaundiced newborns requiring treatment.

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Section: Methodsmentioning

confidence: 99%

Diagnostic Performance Analysis of the Point-of-Care Bilistick System in Identifying Severe Neonatal Hyperbilirubinemia by a Multi-Country Approach

et al. 2018

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“…9 Transcutaneous bilirubin (TcB) test has the advantages of being noninvasive, simple to perform, less expensive, instantaneous results and prevention of repeated blood sampling of tiny baby. [10][11][12] Hyperbilirubinemia is a very common entity in newborns. Screening all the babies for hyperbilirubinemia is must.…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum bilirubin and transcutaneous bilirubin in newborns

Arunachalmath

2021

Int J Contemp Pediatr

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Background: Hyperbilirubinemia is a very common entity in newborns. Screening all the babies for hyperbilirubinemia is must. Serum bilirubin is the standard method of checking the bilirubin in newborns. This is very cumbersome, invasive and time consuming method. Hence many newborns will be discharged without screening. Transcutaneous bilirubinometry would help us in making this task easy and safe. Hence the present study was planned.Methods: This is an institutional cross sectional study conducted in a tertiary care hospital for a period of 6 months. After a written informed consent from parents/ guardians and considering selection criteria, 500 newborns with clinical jaundice were included in study. Each newborn was examined, transcutaneous bilirubin checked at forehead and sternum and serum bilirubin was done at the same time. Data was statistically analyzed to see the correlation between TcB and TSB.Results: Out of 500 newborns, 316 were males, 184 were females and 475 were term gestation and 25 were preterm. Coefficient of correlation was 0.73 and 0.72 for total serum bilirubin versus forehead and sternum respectively which were statistically significant.Conclusions: Transcutaneous bilirubinometer readings closely correlate with that of serum bilirubin. Hence TcB can be used as a safer, economical and effective tool in screening newborns for hyperbilirubinemia.

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“…TcB measurement is used to identify newborns that are at risk of pathological increases in blood bilirubin. Neonatal hyperbilirubinemia occurs in up to ~ 80% of term and preterm newborns in the first week of life [ [7] , [8] , [9] , [10] , [11] ]. However, approximately 2% of infants have total serum bilirubin (TSB) that is considered to be sufficiently elevated for the free unconjugated bilirubin to cross the blood-brain barrier and deposit in the brain [ 7 , 8 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Neonatal hyperbilirubinemia occurs in up to ~ 80% of term and preterm newborns in the first week of life [ [7] , [8] , [9] , [10] , [11] ]. However, approximately 2% of infants have total serum bilirubin (TSB) that is considered to be sufficiently elevated for the free unconjugated bilirubin to cross the blood-brain barrier and deposit in the brain [ 7 , 8 , 12 ]. In rare cases kernicterus, a term often used to describe chronic and/or permanent neurological consequences of this deposition, may also occur without elevated TSB [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…In rare cases kernicterus, a term often used to describe chronic and/or permanent neurological consequences of this deposition, may also occur without elevated TSB [ 13 , 14 ]. Short- and long-term consequences of this deposition can include acute bilirubin encephalopathy, cerebral and/or gaze palsy, delayed development of fine- and gross-motor abilities, mental retardation, and death [ [7] , [8] , [9] , 12 , 15 ]. As such, prompt identification of newborns with a higher-than-normal concentration of bilirubin in the blood is critical to ensure appropriate initiation of treatment, such as phototherapy [ 5 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Improving quality of transcutaneous bilirubin measurements: Value of in-house developed quality control

Paul

Adams

Venner

2021

Practical Laboratory Medicine

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Objectives Quality assurance (QA) plays an integral role in Point of Care Testing (POCT) programs. Quality control (QC) is an important QA program component to ensure high quality results and enhanced patient care. The measurement of transcutaneous bilirubin (TcB) in the POCT setting is an essential part of newborn care in Alberta, Canada. However, there is currently no available commercial QC material for TcB meters. An in-house developed QC material has been in use within a single TcB POCT program within Alberta. The objective of this study was to determine the performance of this QC material by other POCT staff and clinical end-users to assess whether its use could be expanded. Design and methods Two levels of QC material were measured by POCT staff and clinical end-users across 12 different sites using the Dräger Jaundice Meter JM-103® and JM-105® meters. Results The performance of the QC material was acceptable when tested by POCT staff, was stable and reliable over time, and had an acceptable CV (≤8%). However, the data does not support use of the QC material by clinical end-users. Conclusions The use of the QC material could be expanded into other TcB settings for use by POCT staff. Additional training and experience with the QC material by end-users is needed to facilitate QC use in the clinical setting.

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Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns

Abstract: Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns.

Cited by 10 publications

References 32 publications

Diagnostic Performance Analysis of the Point-of-Care Bilistick System in Identifying Severe Neonatal Hyperbilirubinemia by a Multi-Country Approach

Diagnostic Performance Analysis of the Point-of-Care Bilistick System in Identifying Severe Neonatal Hyperbilirubinemia by a Multi-Country Approach

Correlation of serum bilirubin and transcutaneous bilirubin in newborns

Improving quality of transcutaneous bilirubin measurements: Value of in-house developed quality control

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