Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study

Chen, Tung Hua; Lin, Yung Chieh; Lin, Ching‐Hsuan

doi:10.1016/j.pedneo.2018.07.013

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…This highlighted the importance of developing a nomogram for specific populations due to different bilirubin kinetics. Furthermore, among Filipino infants, close monitoring for the development of significant hyperbilirubinemia should be done in the first 72 hours of life (see Figure 5) (10,30,(33)(34)(35)(36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

Applicability of the hour of life approach in hyperbilirubinemia among Filipino term infants

Villanueva-Uy

Amarillo

2022

Front. Pediatr.

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BackgroundHyperbilirubinemia remains a common morbidity among infants. Additional research on bilirubin kinetics and associated risk factors will contribute to providing a more targeted management approach for the Filipino infant.ObjectiveTo develop a Filipino bilirubin nomogram by studying bilirubin patterns during the first 5 days of life.MethodologyThis prospective study recruited 1,412 stable, full-term infants (≥37 weeks age of gestation) born at the Philippine General Hospital (PGH). Using the Dräger-Minolta JM-103 jaundice meter, transcutaneous bilirubin (TcB) levels were determined at the 3rd, 6th, 12th, 24th, 36th, 48th, 72nd, 96th, and 120th hour of life (HOL). A bilirubin nomogram was created using the averages of 3 TcB forehead and sternal measurements at each time epoch. Simultaneous measurement of TcB and total serum bilirubin (TsB) on a subset of 106 infants was done to determine correlation.ResultsCorrelation coefficients were high between TsB and forehead TcB (r2 = 0.88), and between TsB and sternal TcB (r2 = 0.91). The Filipino bilirubin nomogram reflected a steep rise until the 48th hour, followed by plateauing of values. Inadequate nursing and bilirubin levels at 12th and 48th HOL were risk factors for developing significant hyperbilirubinemia at 72nd HOL.ConclusionTcB is a reliable, non-invasive bilirubin screening tool. Among healthy, full-term, Filipino infants, their nomogram features a sudden increase in bilirubin values during the first 48 h, followed by a plateau. To aid in identification of infants at risk for significant hyperbilirubinemia, healthcare providers can assess breastfeeding adequacy and perform bilirubin screening at the 24th−48th HOL. Registration No. (RGAO-2016-0686).

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Section: Discussionmentioning

confidence: 99%

Applicability of the hour of life approach in hyperbilirubinemia among Filipino term infants

Villanueva-Uy

Amarillo

2022

Front. Pediatr.

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“…In recent years, the ready availability of modern TcB measuring devices has made the evaluation of neonatal jaundice more objective and more accurate than subjective visual assessment and "has taken the guesswork out of jaundice evaluation." 17 In contrast to the single serum-based nomogram, an abundance of hour-specific nomograms constructed from TcB measurements have been published [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] (Table I; available at www.jpeds.com). This is not surprising as, unlike serum bilirubin testing, TcB sampling does not involve painful blood drawing procedures, and gathering TcB data for nomogram construction is, therefore, relatively easy.…”

Section: Bilirubin Nomogramsmentioning

confidence: 99%

Variation in Transcutaneous Bilirubin Nomograms across Population Groups

Kaplan

Bromiker

2019

The Journal of Pediatrics

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“…Neonatal jaundice is a common condition that frequently presents in 1-2 wk old neonates, and is one of the most common causes of hospital admission of young infants, especially in Asia [1]. A study revealed the mean TcB values ranged from 2.7 ± 1.3 to 14.2 ± 2.9 mg/dL of the newborns in the first week after birth in a tertiary hospital in Taiwan [2]. The yellow discoloration of the skin and sclera is the result of the accumulation of unconjugated bilirubin.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive transcutaneous bilirubin assessment of neonates with hyperbilirubinemia using a photon diffusion theory-based method

Cheng

Lin

Fang

et al. 2019

Biomed. Opt. Express

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Transcutaneous bilirubinometers are widely used to screen neonatal jaundice. However, it was reported that their accuracy is compromised at low and high bilirubin levels. We used a photon diffusion theory-based method valid in the 450-600 nm wavelength region to overcome this obstacle. Our clinical study results showed that our system could properly determine the transcutaneous bilirubin concentrations at total serum bilirubin levels higher than 14 mg/dL, where a commercial bilirubinometer failed to provide proper results in several cases. These findings suggested that photon diffusion theory could be employed to improve the core algorithm of modern bilirubinometers and enhance their applicability.

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Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study

Abstract: A 12-h specific TCB nomogram could be a useful reference for workup for hyperbilirubinemia, particularly when it is above the 95th percentile line.

Cited by 5 publications

References 28 publications

Applicability of the hour of life approach in hyperbilirubinemia among Filipino term infants

Applicability of the hour of life approach in hyperbilirubinemia among Filipino term infants

Variation in Transcutaneous Bilirubin Nomograms across Population Groups

Noninvasive transcutaneous bilirubin assessment of neonates with hyperbilirubinemia using a photon diffusion theory-based method

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