Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application

Wang, Yu; Li, Shaoyuan; Wang, Dan; Wu, Mozheng; He, Jia-Kai; Zhang, Jinling; Zhao, Bin; Hou, Liwei; Wang, Junying; Wang, Lei; Wang, Yi-Fei; Zhang, Yue; Zhang, Zixuan; Rong, Peijing

doi:10.1007/s12264-020-00619-y

Cited by 55 publications

(42 citation statements)

References 88 publications

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“…Here we will use taVNS to refer to all transcutaneous VNS acting on the ear ( Badran et al, 2019 ; Farmer et al, 2020 ). This section is not intended to be an exhaustive review of all taVNS applications, however, we have chosen a representative pool of work from the rapidly growing field of neurological and psychiatric taVNS applications ( Wang et al, 2021 ).…”

Section: Transcutaneous Auricular Vagus Nerve Stimulation (Tavns)mentioning

confidence: 99%

A Review of Parameter Settings for Invasive and Non-invasive Vagus Nerve Stimulation (VNS) Applied in Neurological and Psychiatric Disorders

et al. 2021

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Vagus nerve stimulation (VNS) is an established form of neuromodulation with a long history of promising applications. Earliest reports of VNS in the literature date to the late 1800’s in experiments conducted by Dr. James Corning. Over the past century, both invasive and non-invasive VNS have demonstrated promise in treating a variety of disorders, including epilepsy, depression, and post-stroke motor rehabilitation. As VNS continues to rapidly grow in popularity and application, the field generally lacks a consensus on optimum stimulation parameters. Stimulation parameters have a significant impact on the efficacy of neuromodulation, and here we will describe the longitudinal evolution of VNS parameters in the following categorical progression: (1) animal models, (2) epilepsy, (3) treatment resistant depression, (4) neuroplasticity and rehabilitation, and (5) transcutaneous auricular VNS (taVNS). We additionally offer a historical perspective of the various applications and summarize the range and most commonly used parameters in over 130 implanted and non-invasive VNS studies over five applications.

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Section: Transcutaneous Auricular Vagus Nerve Stimulation (Tavns)mentioning

confidence: 99%

A Review of Parameter Settings for Invasive and Non-invasive Vagus Nerve Stimulation (VNS) Applied in Neurological and Psychiatric Disorders

et al. 2021

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“…Non-invasiveness, reversibility and the possibility of a rapid start of therapy broaden the spectrum of symptoms and diseases that can be treated. Clinical applications and investigations span from cardiovascular and digestive system diseases (Kaniusas et al, 2019 ; Wang et al, 2020 ), insomnia (Wu et al, 2021 ), tinnitus (Stegeman et al, 2021 ), pain (Kaniusas et al, 2019 ), migraine (Straube et al, 2015 ) as well as to disorders of consciousness (Briand et al, 2020 ), aging (Bretherton et al, 2019 ), and cognitive impairment (Colzato and Beste, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global

et al. 2021

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Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive brain stimulation technique considered as a potential supplementary treatment option for a wide range of diseases. Although first promising findings were obtained so far, the exact mode of action of taVNS is not fully understood yet. We recently developed an examination schedule to probe for immediate taVNS-induced modifications of large-scale epileptic brain networks. With this schedule, we observed short-term taVNS to have a topology-modifying, robustness- and stability-enhancing immediate effect on large-scale functional brain networks from subjects with focal epilepsies. We here expand on this study and investigate the impact of short-term taVNS on various local and global characteristics of large-scale evolving functional brain networks from a group of 30 subjects with and without central nervous system diseases. Our findings point to differential, at first glance counterintuitive, taVNS-mediated alterations of local and global topological network characteristics that result in a reconfiguration of networks and a modification of their stability and robustness properties. We propose a model of a stimulation-related stretching and compression of evolving functional brain networks that may help to better understand the mode of action of taVNS.

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“…With further improvement in technology, taVNS is expected to play an important role in more diseases. At present, the stimulation parameters, intensity, and potential mechanism of taVNS in treating different diseases need to be further evaluated (Wang et al, 2020). In this study, we only preliminarily explored the mechanism of taVNS in treating PI, which may provide the basis for further research.…”

mentioning

confidence: 99%

Effects of transcutaneous auricular vagus nerve stimulation on brain functional connectivity of medial prefrontal cortex in patients with primary insomnia

Zhang

Meng

et al. 2021

The Anatomical Record

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As a representative of acupuncture and nonpharmaceutical therapy, auricular acupuncture has been widely for the treatment of insomnia. Transcutaneous auricular vagus nerve stimulation (taVNS) is a combination of auricular point stimulation and vagus nerve stimulation. It can not only treat primary insomnia effectively, but also is noninvasive, painless, portable and economical. The medial prefrontal cortex (mPFC) is a core region of default mode network (DMN), which is important for maintenance of sleep. However, the mechanism of taVNS in alleviating primary insomnia (PI) remains to be clarified. In this study, we found that taVNS could not only effectively reduce the score of Pittsburgh Sleep Quality Index, but also decreased functional connection (FC) between the left mPFC and bilateral dorsal anterior cingulate gyrus as well as FC between the right mPFC and the occipital cortex in patients with PI. Furthermore, the decrease in FC was positively correlated with the decline of sleep index score. Therefore, we proposed that treatment with taVNS can improve sleep quality and prolong sleep duration in patients with PI by reducing FC within DMN, FC between DMN and salience network, as well as FC between DMN and the occipital cortex. This may be one of mechanisms of taVNS in treating PI.

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Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application

Cited by 55 publications

References 88 publications

A Review of Parameter Settings for Invasive and Non-invasive Vagus Nerve Stimulation (VNS) Applied in Neurological and Psychiatric Disorders

A Review of Parameter Settings for Invasive and Non-invasive Vagus Nerve Stimulation (VNS) Applied in Neurological and Psychiatric Disorders

Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global

Effects of transcutaneous auricular vagus nerve stimulation on brain functional connectivity of medial prefrontal cortex in patients with primary insomnia

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