Abstract:Transcription factors (TFs) regulate gene expression via binding to specific sequence motifs in promoters or enhancers. They are involved in various biological processes and their aberrant action may lead to multiple pathological states. To better understand the function of a given TF, it is necessary to identify its crucial binding sites and target genes, which is not a trivial task. CRISPR/Cas9 has been recently successfully applied in the study of TFs. Here, we present an online tool, transCRISPR, created t… Show more
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