“…Genome-scale metabolic models of S. erythraea and S. spinosa were used to identify the effects of supplementing amino acids in media on production yield, 44,58 while those of A. balhimycina, S. coelicolor and S. tsukubaensis were used to identify gene manipulation targets to enhance target production. 45,60,61 In these metabolic models, only experimentally known secondary metabolite biosynthetic pathways were considered. For example, separate biosynthetic pathways for actinorhodin, undecylprodigiosin, calcium-dependent antibiotic, ectoine, and germicidin were included in the latest version of the S. coelicolor metabolic model, 45 while the S. erythraea metabolic model describes biosynthetic pathways for erythromycin, 2-methylisoborneol, rhamnosylaviolin, and erythrochelin.…”