Transcriptomic Validation of the Protective Effects of Aqueous Bark Extract of Terminalia arjuna (Roxb.) on Isoproterenol-Induced Cardiac Hypertrophy in Rats

Abstract

Cardioprotection by Terminalia arjuna During Stress Signaling Kumar et al.

Protective Effect of Arjunakwatha and Arjunasheeta in Paracetamol-induced Kidney Injury in Rat Model

“…Arjunakwaatha and Arjunasheetha contain various antioxidant components due to their being prepared from bark of Terminalia arjuna (TA). 22 Giri et al found that an aqueous extract of TA lowered urea and creatinine levels in rats with paracetamol-induced CKD, 13 which matched the results of the current investigation. Arjunakwaatha and Arjunasheeta improved kidney tissue antioxidant capacity and reduced the concomitant oxidative stress, as indicated by elevations in GSH levels and SOD activity, an increase in CAT activity, and the decreases in the tissue levels of MDA compared to those of kidney injury rats (Figure 8).…”

“…[18][19][20] Excess paracetamol causes the overproduction of reactive oxygen species (ROS) in kidney tissue by altering the oxidant-antioxidant balance with an increase in lipid peroxidation. 22 In the study, we observed that paracetamol treated rats were associated with increased MDA levels and a significant decrease in SOD, CAT, and GSH activity. The SOD-CAT-GSH renal antioxidant enzyme axis maintains the oxidant-antioxidant balance in the normal kidney where disbalance of that axis indicates kidney injury 20 (Figure 8).…”

Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12‐dimethylbenz[a]anthracene‐induced hamster oral cancer via the down‐regulation of PI3K/AKT/mTOR signaling pathways

“…The accumulation of ROS or antioxidant potential in efficiency are probably TBARS levels enhanced in plasma in DMBA treated hamsters. Lowered the enymatic and nonenzymatic antioxiants by remove excessive formation of antioxidant 46,47 . Orally treated TQ/Ca‐alg‐PVA to DMBA administered hamsers showed regained the level of plasma lipid peroxidation and anti‐oxidants capabilities.…”

Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets

“…In this regard, several naturally occurring compounds have been shown to alleviate the hypertrophic phenotype through suppression of oxidative stress. For instance, the pulp powder extracted from Musa balbisiana (banana) [90], the lowbush blueberry extract (Vaccinium angustifolium) [91], the aqueous extract of the Terminalia arjuna bark [92] and pomegranate juice [93] have been associated with reduction in heart weight, fibrosis, inflammation and oxidative stress. In addition to supressing cardiac hypertrophy, these compounds have been reported to exert beneficial effects across several pathologies suggestive of pleiotropic function.…”