Transcriptomic profiling of peripheral blood CD4+ T-cells in asthmatics with and without depression

Wang, Ting; Ji, Yulin; Yang, Yinyin; Xiong, Xingyu; Wang, I‐Ming; Sandford, Andrew J.; Liang, Zong-An; He, Jian‐Qing

doi:10.1016/j.gene.2015.04.029

Cited by 15 publications

(13 citation statements)

References 42 publications

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“…28 Another study on gene expression of blood CD4 + T cells from comorbid patients showed that the main active pathways in depressive asthma are IL-6 and CRP signalling. 29 In our study, the acute in ammatory mediator IL-6 was elevated signi cantly in A + D group. This nding is partly in accordance with a previous Meta-analysis illustrating that concentrations of cytokines such as IL-1, IL-4, IL-6, TNF-α were higher in depressive patients than non-depressive controls.…”

Section: Discussionsupporting

confidence: 49%

Higher inflammation and cerebral white matter injury associated with cognitive deficit in asthmatic patients with depression

et al. 2020

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Background Depression is a common co-morbidity in asthma, worsening asthma control and impairing patient's quality of life. Previous studies have reported a higher risk of cognitive de cit in depression. However, few research has focused on the cognitive status of asthmatic patients with depression. Evidence showed that in ammation may play an important role in both asthma and depression. Moreover, cerebral white matter injury, which could be induced by in ammation, has been associated with depression. The present study aimed to assess the cognitive function and explore the potential mechanism in patients with asthma, depression and comorbidity. Methods We admitted four groups: Asthma comorbid Depression group (A + D, n = 26), Depression group (D, n = 25), Asthma group (A, n = 33) and Normal controls (N, n = 28). Cognitive function was assessed by Montreal Cognitive Assessment (MoCA). Various in ammatory cytokines were measured, including interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-mobility group box 1(HMGB1) and Netrin-1. Cerebral white matter injury was assessed by serum myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG), and their correlations with cognitive performance were calculated. Results A + D group showed the highest incidence of cognitive de cit with speci c affected cognitive domain. Compared to N group, serum levels of IL-6, HMGB1, Netrin-1, MBP and MOG were signi cantly elevated in A + D group. MOG level was negatively correlated with MoCA score. Conclusion Patients with comorbid condition presented more de nite, severe cognitive de cit and higher level of in ammatory cytokines. Cerebral white matter injury may account for the cognitive de cit in these patients and MOG could be a potential biomarker of this process.

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Section: Discussionsupporting

confidence: 49%

Higher inflammation and cerebral white matter injury associated with cognitive deficit in asthmatic patients with depression

et al. 2020

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“…The heterogeneity and comorbid conditions in elderly individuals with asthma are major relevant factors. In a recent whole-genome study, individuals with asthma who presented with depression expressed higher levels of the phosphoinositide 3-kinase signaling pathway in CD4+ T cells, which supports the possibility that Th1/Th2 differentiation is associated with depressive asthma [40]. Unlike in children and young adults, the role of immunoglobulin E (IgE)-mediated atopy in elderly individuals with asthma is not fully elucidated.…”

Section: Discussionmentioning

confidence: 98%

Chronic cough, not asthma, is associated with depression in the elderly: a community-based population analysis in South Korea

Sohn

Song

Kim

et al. 2019

Korean J Intern Med

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Background/AimsDepression and allergic diseases, including asthma, are frequently reported as comorbid conditions. However, their associations have been rarely examined in community-based elderly populations.MethodsThe analyses were performed using the baseline data set of the Korean Longitudinal Study of Health and Aging, which consists of 1,000 elderly participants (aged > 65 years) randomly recruited from an urban community. Depression was assessed using the Geriatric Depression Scale, Center for Epidemiologic Studies Depression Scale, and Hamilton Rating Scale for Depression. Major and minor depressive disorders were diagnosed by psychiatrists. Allergic conditions were assessed using structured questionnaires, lung function, and skin prick test. Quality of life and comorbidities were assessed using structured questionnaires.ResultsPrevalence of asthma and major depressive disorder were 5.4% and 5.3%, respectively. The rate of depression was not significantly different between the non-asthmatic and asthmatic groups. No correlation was observed between the scores obtained using the depression scales and self-reported asthma. However, chronic, frequent, and nocturnal cough were significantly associated with depression and scores obtained using the depression scales, which remained significant in multivariate logistic regression analyses (chronic cough: odds ratio [OR], 3.23; 95% confidence interval [CI], 2.57 to 12.74; p = 0.04). Rhinitis was independently associated with high Mini-Mental State Examination scores (OR, 1.11; 95% CI, 1.05 to 1.17; p < 0.001) and low 36-item short-form (OR, 0.96; 95% CI, 0.80 to 0.98; p = 0.002).ConclusionsDepression may not be significantly associated with asthma and allergic diseases in elderly populations, but cough is a significant factor affecting depression.

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“…A recent study on gene expression of blood CD4+ T cells from patients with depression and asthma showed that the main active pathways in depressive asthma are those related to acute phase protein signalling (such as IL-6 and CRP signalling) [ 149 ]. Chronic stress may lead to dysregulation of hypothalamic-pituitary-adrenal (HPA) axis, long-term increase in the levels of cortisol, glucocorticoid resistance, and systemic inflammation.…”

Section: Mechanisms Linking Asthma With Its Comorbiditiesmentioning

confidence: 99%

Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms

Kankaanranta

Kauppi

Tuomisto

et al. 2016

Mediators of Inflammation

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Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an important factor in separating the phenotypes. Most studies with asthma have been performed in patients being otherwise healthy. However, in real life, comorbid diseases are very common in adult patients. We review here the emerging comorbid conditions to asthma such as obesity, metabolic syndrome, diabetes mellitus type 2 (DM2), and cardiac and psychiatric diseases. Their role as risk factors for incident asthma and whether they affect clinical asthma are evaluated. Obesity, independently or as a part of metabolic syndrome, DM2, and depression are risk factors for incident asthma. In contrast, the effects of comorbidities on clinical asthma are less well-known and mostly studies are lacking. Cross-sectional studies in obese asthmatics suggest that they may have less well controlled asthma and worse lung function. However, no long-term clinical follow-up studies with these comorbidities and asthma were identified. These emerging comorbidities often occur in the same multimorbid adult patient and may have in common metabolic pathways and inflammatory or other alterations such as early life exposures, systemic inflammation, inflammasome, adipokines, hyperglycemia, hyperinsulinemia, lung mechanics, mitochondrial dysfunction, disturbed nitric oxide metabolism, and leukotrienes.

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Transcriptomic profiling of peripheral blood CD4+ T-cells in asthmatics with and without depression

Cited by 15 publications

References 42 publications

Higher inflammation and cerebral white matter injury associated with cognitive deficit in asthmatic patients with depression

Higher inflammation and cerebral white matter injury associated with cognitive deficit in asthmatic patients with depression

Chronic cough, not asthma, is associated with depression in the elderly: a community-based population analysis in South Korea

Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms

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