Transcriptomic profiling of long non-coding RNAs in hepatitis B virus-related hepatocellular carcinoma

Fan, Hongxia; Zhang, Qiaoge; Zhao, Xiaopei; Lv, Ping; Liu, Min; Tang, Hua

doi:10.18632/oncotarget.18897

Cited by 18 publications

(16 citation statements)

References 35 publications

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“…Similar genome-wide lncRNA profiling studies carried out by other groups have invariably pointed to the general conclusion of widespread lncRNA dysregulation in HCC. An RNA-sequencing study of HBV-related HCC samples revealed a total of 1242 dysregulated lncRNA transcripts (983 up-regulated and 259 down-regulated) [ 73 ]. In another study of 12 HCC tissues and paired adjacent normal tissues, the authors identified 214 differentially expressed lncRNAs, among which 17 were further confirmed in 21 paired HCC and normal liver tissues via quantitative real-time PCR [ 74 ].…”

Section: Widespread Lncrna Dysregulation In Hccmentioning

confidence: 99%

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

Lanzafame

Bianco

Terracciano

et al. 2018

IJMS

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Whole-transcriptome analyses have revealed that a large proportion of the human genome is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs (lncRNAs). Rather than being “transcriptional noise”, increasing evidence indicates that lncRNAs are key players in the regulation of many biological processes, including transcription, post-translational modification and inhibition and chromatin remodeling. Indeed, lncRNAs are widely dysregulated in human cancers, including hepatocellular carcinoma (HCC). Functional studies are beginning to provide insights into the role of oncogenic and tumor suppressive lncRNAs in the regulation of cell proliferation and motility, as well as oncogenic and metastatic potential in HCC. A better understanding of the molecular mechanisms and the complex network of interactions in which lncRNAs are involved could reveal novel diagnostic and prognostic biomarkers. Crucially, it may provide novel therapeutic opportunities to add to the currently limited number of therapeutic options for HCC patients. In this review, we summarize the current status of the field, with a focus on the best characterized dysregulated lncRNAs in HCC.

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Section: Widespread Lncrna Dysregulation In Hccmentioning

confidence: 99%

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

Lanzafame

Bianco

Terracciano

et al. 2018

IJMS

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“… 1 Etiologically, chronic infections of hepatitis B and C viruses, aflatoxin B1 exposure, and alcohol abuse are the primary risk factors for HCC occurrence. 2 , 3 Alcohol intake varies among cultures, but is prevalent around the world and likely to induce alcohol dependence in heavy drinkers, which account for approximately 14% of the general population, 4 approximately 10–15% of whom are at high risk of liver cirrhosis, including a small percentage at an exceptional risk for many types of cancers. 5 , 6 It is well documented that liver cirrhosis can eventually impel the occurrence of HCC.…”

Section: Introductionmentioning

confidence: 99%

Genetic variants of <em>ALDH2</em>-rs671 and <em>CYP2E1</em>-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population

Wang

Shang

et al. 2018

CMAR

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ObjectiveAcetaldehyde dehydrogenase 2 (ALDH2) and cytochrome P450 2E1 (CYP2E1) have been associated with hepatocellular carcinoma (HCC) susceptibility and prognosis. The polymorphisms ALDH2 rs671 and CYP2E1 rs2031920 are reportedly correlated with the prevalence of HCC in other countries. The aim of this study was to investigate associations between ALDH2 and CYP2E1, and HCC susceptibility in a population of Guangxi, southern China, an area with a high incidence of HCC.Patients and methodsThe study cohort included 300 HCC cases, 292 healthy controls for HCC susceptibility analysis, and another 20 HCC cases and 10 healthy controls for ascertainment. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method.ResultsThe study results demonstrated that mutant genotypes of ALDH2 (G/A and A/A) led to significant differences in HCC susceptibility, as compared with the wild genotype (G/G) with the same C1/C1 genotype in non-drinking individuals (adjusted P=0.010, OR=0.20, 95% CI=0.06–0.68). The mutant genotypes of CYP2E1 (C1/C2 and C2/C2) brought about significant differences in HCC susceptibility, as compared with the wild genotype (C1/C1) and the same G/G genotype (adjusted P=0.025, OR=0.42, 95% CI=0.20–0.90). Drinking plays a role in HCC susceptibility in the same G/G genotype individuals (adjusted P=0.004, OR=0.32, 95% CI=0.15–0.69), but had no impact when combined with CYP2E1 for analysis (all P>0.05).ConclusionThese results suggest that the mutant genotypes of ALDH2 and CYP2E1 may be protective factors for HCC susceptibility in Guangxi province, China.

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“…It has been reported that the HBV virus affects tumor cell growth and associated microRNA (miR) production (31), and it has been revealed that HBeAg-induced miR-106b expression contributes to the pathogenesis of HBV-associated liver cancer by downregulating the retinoblastoma gene (32). Furthermore, various long non-coding RNAs serve functional roles in HBV-associated hepatic carcinoma by regulating biological processes (33,34).…”

Section: Discussionmentioning

confidence: 99%

Exosomes derived from HBV‑associated liver cancer promote chemoresistance by upregulating chaperone‑mediated autophagy

Liu

Guo

et al. 2018

Oncol Lett

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Liver cancer, which is the second leading cause of tumor-associated mortality, is of great concern worldwide due to its resistance to chemotherapeutic drugs. Transcatheter arterial chemoembolization (TACE) has previously been used as a treatment for unresectable liver tumors in China; however, the response to TACE treatment differs between patients. It has been reported that hepatitis B virus (HBV)-as sociated tumors are less sensitive to TACE treatment compared with non-HBV-associated liver cancer. Previous studies have demonstrated that exosomes serve a crucial role in hepatic carcinoma chemoresistance. We therefore hypothesized that HBV may modulate chemosensitivity via exosomes. The aim of the present study was to investigate how exosomes affect chemoresistance by assessing their role in chaperone-mediated autophagy (CMA)-dependent chemoresistance in HBV-associated liver cancer. Iconography data from HBV-positive and HBV-negative patients with hepatic carcinoma receiving TACE treatment were assessed, and it was revealed that the tumor volume was decreased in the patients with non-HBV-associated liver cancer compared with that in the patients with HBV-associated tumors following TACE therapy. Furthermore, it was revealed that exosomes from HBV-infected liver cancer cells were able to downregulate cell apoptosis when treated with oxaliplatin compared with exosomes from normal HepG2 cells. Furthermore, the results demonstrated that HBV-associated exosomes modulate cell death via activating the CMA pathway, and its key molecule, lysosome-associated membrane protein (Lamp2a), was also upregulated. Lamp2a-knockdown was also found to reverse anti-apoptotic effects in liver cancer. Taken together, the results of the present study suggest that chemoresistance in patients with HBV-associated hepatic tumors may be mediated by exosomes, and thus may provide a basis for the development of novel treatment strategies for chemoresistant liver cancer.

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Transcriptomic profiling of long non-coding RNAs in hepatitis B virus-related hepatocellular carcinoma

Cited by 18 publications

References 35 publications

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

Genetic variants of <em>ALDH2</em>-rs671 and <em>CYP2E1</em>-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population

Exosomes derived from HBV‑associated liver cancer promote chemoresistance by upregulating chaperone‑mediated autophagy

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