Transcriptomic profiling identified altered expression of genes associated with testicular functions in adult F1 rats exposed to carbimazole during fetal period

Background Ameliorating the complications of pharmaceutical drugs by natural compounds or probiotics is now a medical strategy. The anti-thyroid drug carbimazole was reported to cause some complications as liver and kidneys dysfunction besides the harmful effect on the structure of the thyroid gland in addition to weight gain during thyroid treatment. The aim of the present work was suggesting xylo-oligosaccharides extracted from Aspergillus terreus xylanase degradation of xylan for the first time as a candidate for ameliorating some of the drug-associated complications. Results The present work reported that the administration of carbimazole drug only to female Wistar rats for three weeks leads to significant decrease in serum levels of ALT, AST and urea (p ≤ 0.05) which reflected a status of a lazy liver. On the other hand, there was a significant increase in serum levels of total protein content, creatinine and calcium (p ≤ 0.05). A detected non-significant decrease in serum T4 accompanied with significant increased levels of T3 (p ≤ 0.05) and a normal serum TSH were observed in this group compared to the control group. Histological examinations on liver, kidneys and thyroid tissues revealed the effect of the drug on their cells shape which reflected the malfunction of these organs. Co-administration of xylo-oligosaccarides to carbimazole in rats significantly improved most of the changed serum parameters levels in addition to a marked modulation in the histological examination of both the liver and kidney tissues. More histological modulations were displayed in the thyroid tissues than those observed in liver and kidneys tissues. Conclusion Accordingly, it can be concluded that xylo-oligosaccarides extracted from Aspergillus terreus xylanase degradation of xylan are suggested to be a safe therapy in ameliorating carbimazole drug-associated complications.

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Transcriptomic profiling identified altered expression of genes associated with testicular functions in adult F1 rats exposed to carbimazole during fetal period

Cited by 2 publications

References 60 publications

Antioxidant effects of α-lipoic acid against epididymal oxidative damage in adult offspring rats exposed to maternal hypothyroidism stress

Antioxidant effects of α-lipoic acid against epididymal oxidative damage in adult offspring rats exposed to maternal hypothyroidism stress

Role of xylo-oligosaccharides in relieving complications accompanied to carbimazole drug administrated with 1% saline in female Wistar rats

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