Transcriptomic profiling highlights cell proliferation in the progression of experimental pulmonary hypertension in rats
Ang Luo,
Rongrong Hao,
Xia Zhou
et al.
Abstract:Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remolding and occlusion, leading to the elevated pulmonary arterial pressures, right ventricular hypertrophy, and eventual heart failure if left untreated. Understanding the molecular mechanisms underlying the development and progression of pulmonary hypertension (PH) is crucial for devising efficient therapeutic approaches for the disease. Lung homogenates were collected weekly and underwent RNA-sequencing in th… Show more
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