Abstract:Cantharidin (CTD), extracted from the traditional Chinese medicine
mylabris, has shown significant curative effects against a variety of
tumors, but its clinical application is limited by its nephrotoxicity,
and the underlying molecular mechanisms remain unclear. In this study,
we investigated the toxic effects in mouse kidneys following CTD
treatment by pathological observations, biochemical index detection, and
transcriptomics, and explored the underlying molecular mechanisms by RNA
sequencing (RNA-seq). The… Show more
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