Abstract:Background: Studies demonstrated that age-related cellular and functional changes of airway significantly contribute to the pathogenesis of many airway diseases. However, our understanding on the age-related molecular alterations of human airway remains inadequate.Methods: Airway (trachea and bronchus) brushing specimens were collected from 14 healthy, female non-smokers with ages ranging from 20 to 60 years. Bulk RNA sequencing was performed on all the specimens (n = 28). Airway cell types and their relative … Show more
“…However, pathological COPD is an environmental factor. Secondhand smoke exposure is the risk of pathological COPD [9]. Therefore, chronic inflammation plays a critical role in COPD disease processes.…”
“…However, pathological COPD is an environmental factor. Secondhand smoke exposure is the risk of pathological COPD [9]. Therefore, chronic inflammation plays a critical role in COPD disease processes.…”
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