Transcriptomic pathology of neocortical microcircuit cell types across psychiatric disorders
Keon Arbabi,
Dwight F. Newton,
Hyunjung Oh
et al.
Abstract:Background: Psychiatric disorders like major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are characterized by altered cognition and mood, brain functions that depend on information processing by cortical microcircuits. We hypothesized that psychiatric disorders would display cell type-specific transcriptional alterations in neuronal subpopulations that make up cortical microcircuits: excitatory pyramidal (PYR) neurons and vasoactive intestinal peptide- (VIP), somatostatin- (SST), … Show more
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