Transcriptomic Gene Network Profiling and Weak Signal Detection for Prediction of Ovarian Cancer Occurrence, Survival, and Severity by Integrating Bulk and Single-cell RNAseq Data
Yanming Li,
Mihaela Sardiu,
Devin C. Koestler
et al.
Abstract:BackgroundOvarian cancer (OC) is a significant gynecological malignancy characterized by its high mortality rate, poor long-term survival rate, and late-stage diagnosis. OC is the 5th leading cause of cancer death among woman and counts 2.1% of all cancer death. OC survival rates are much lower than other cancers that affect woman. Its 5-year survival rate is less than 50%. Only ∼17% of OC patients are diagnosed within the early stage. The majority are diagnosed at an advanced stage, making early detection and… Show more
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