Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration
Jiayi Wu,
Feifei Li,
Peng Yu
et al.
Abstract:Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal regeneration. Despite extensive studies on mineralized parenchymal tissue rebuilding, regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances yet. Current knowledge has evidenced the indispensability of rebuilding suture mesenchymal stem cell niches to avoid severe brain or even systematic damage. But to date, the absence of promising therapeutic… Show more
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