Transcriptomic Analysis of Blaschko-Linear Psoriasis Reveals Shared and Distinct Features with Psoriasis Vulgaris

Onoufriadis, Alexandros; Niazi, Umar; Dimitrakopoulou, Konstantina; Reich, Jeremias; Ainali, Chrysanthi; Papanikolaou, Maria; Kesidou, Evangelia; Hsu, Chao‐Kai; Saqi, Mansoor; McGrath, John A.; Reich, Kristian

doi:10.1016/j.jid.2021.07.007

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…1 , Supplementary heatmap reorder of Fig. 1 ) [ 15 ]. However, further research is needed to clarify the pathogenic genes of linear psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Chen,

Cheng,

Peng

et al. 2024

Dermatol Ther (Heidelb)

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Introduction Blaschko linear psoriasis (BLP) is characterized by the linear distribution of psoriatic skin lesions along the Blaschko lines. BLP can be divided into type I and type II, mainly on the basis of clinical manifestations. BLP can easily cause psychological burdens in patients and clinical confusion for physicians. Here, we summarize clinical cases to provide a better understanding of BLP. Methods The subjects included patients with BLP who visited our dermatology departments and those reported in the literature obtained from the PubMed and Wanfang databases. Quantitative data were presented as means ± SD (standard deviation), and qualitative data were represented by the frequency. Student’s t test was employed to compare means, whereas chi-square tests were used for analyzing qualitative data. Results A total of 74 patients with BLP (5 our patients, 69 from literature) were included, with 61 type I and 13 type II patients. We summarize BLP’s characteristics as follows: (1) More frequent in male individuals, especially in type II; (2) Earlier onset than classical psoriasis; (3) Mainly distributed unilaterally, and no preference for left or right site; (4) Asymptomatic or slight pruritus; (5) Mostly negative family history of psoriasis; (6) Possible involvement of the nails/scalp (mainly for type II); (7) Possible exogenous triggering or aggravation factors; (8) Possible concomitant classical plaque or guttate psoriasis lesions, especially in type II; (9) Conforming to histopathology features of classical psoriasis; (10) Relatively favorable response to antipsoriatic treatment, although poor for superimposed areas in type II. Conclusion This study analyzed the clinical characteristics and therapeutic aspects of BLP. Compared with published studies, we have new findings, such as gender bias. Besides traditional antipsoriatic treatment, a personalized selection of biologics may also be a promising choice. Dermatologists should recognize and understand the significance of this disease, and provide patients with appropriate psychological counseling and clinical treatments. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-024-01140-0.

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“…1 , Supplementary heatmap reorder of Fig. 1 ) [ 15 ]. However, further research is needed to clarify the pathogenic genes of linear psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Chen,

Cheng,

Peng

et al. 2024

Dermatol Ther (Heidelb)

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“…We also obtained one 4-mm punch biopsy from each of 6 healthy control subjects (HC), carefully matched for age, sex, ethnicity, body site and biopsy time (see Table S1 for participant details). Based on more recent transcriptomic studies undertaken in our group 13,14 with as low as 2 patients 14 and just 3 patients in a complex trait disease study performed by others, 15 albeit using RNA-Seq technology, we considered our rare disease sample size to be adequate to obtain robust data. We defined chronic wounds as those present for at least 6 weeks with no signs of active wound healing.…”

Section: Skin Biopsy Sample Processingmentioning

confidence: 99%

Transcriptomic profiling of recessive dystrophic epidermolysis bullosa wounded skin highlights drug repurposing opportunities to improve wound healing

Onoufriadis

Proudfoot

Ainali³

et al. 2021

Experimental Dermatology

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Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a severe inherited blistering skin disorder caused by mutations in COL7A1, encoding type VII collagen (C7), the major anchoring fibril protein at the dermal-epidermal junction. 1,2 Although loss of C7 underlies the mucocutaneous fragility in RDEB, the major disease burden results from frustrated attempts at tissue repair, in which normal processes of granulation tissue formation, immune cell infiltration, re-epithelialisation and extracellular matrix remodelling are compromised. This disruption leads to delayed wound healing, chronic inflammation, fibrosis, scarring and an increased risk of squamous

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Transcriptomic Analysis of Blaschko-Linear Psoriasis Reveals Shared and Distinct Features with Psoriasis Vulgaris

Cited by 2 publications

References 14 publications

Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Clinical Characteristics and Therapeutic Aspects of Blaschko Linear Psoriasis

Transcriptomic profiling of recessive dystrophic epidermolysis bullosa wounded skin highlights drug repurposing opportunities to improve wound healing

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