“…Recent MAIT cell transcriptomes, including single-cell transcriptomes, have differentiated various MAIT cell subsets in mice ( Chandra et al., 2021 ; Tao et al., 2021 ) and humans ( Vorkas et al., 2022 ). Moreover, human MAIT cell stimulation through signaling, cytokines, anti-CD3/CD28, or bacterial infections display transcriptomes associated with tissue repair ( Hinks et al., 2019 ; Leng et al., 2019 ; Chandra et al., 2021 ; Tao et al., 2021 ; Vorkas et al., 2022 ), polyfunctional effector functions ( Koay et al., 2019 ; Lamichhane et al., 2019 ; Salou et al., 2019 ; Lee et al., 2020 ), and innate-like activation programs ( Sharma et al., 2020 ). However, MAIT cells stimulated by MR1 antigen presentation with different bacterial infections or stimulations display heterogeneous responses that have been considered as pathogen selectivity, labeled with diverse sequences of TCRβ chain and an invariant α chain, and attributed to potentially different antigens from various bacteria ( Reantragoon et al., 2013 ; Gold et al., 2014 ; Jiang et al., 2014 ; Lepore et al., 2014 ; Sakala et al., 2015 ; Meermeier et al., 2016 ).…”