Transcriptome-Wide Analysis of Low-Concentration Exposure to Bisphenol A, S, and F in Prostate Cancer Cells

Cortés-Ramírez, Sergio Alberto; Salazar, Ana María; Sordo, Monserrat; Ostrosky‐Wegman, Patricia; Morales-Pacheco, Miguel; Cruz-Burgos, Marian; Losada-García, Alberto; Rodríguez-Martínez, Griselda; González-Ramírez, Imelda; Vázquez-Santillán, Karla; González-Covarrubias, Vanessa; Maldonado, Vilma; Rodríguez-Dorantes, Mauricio

doi:10.3390/ijms24119462

Cited by 3 publications

(2 citation statements)

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“…Talking about other bisphenols, studies are in fair numbers suggesting their role in causing cancers. BPS and BPF are also linked to endocrine‐driven cancers and prostate cancer cells 47 . Bisphenol P and M are known to aggravate the metastasis in triple‐negative breast cancer cell lines 48 .…”

Section: Bisphenols Endocrine Disruption and Carcinogenicitymentioning

confidence: 99%

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Sangwan,

Bhattacharyya,

Banerjee

2024

Liver International

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Plastics, while providing modern conveniences, have become an inescapable source of global concern due to their role in environmental pollution. Particularly, the focus on bisphenol A (BPA) reveals its biohazardous nature and association with liver issues, specifically steatosis. However, research indicates that BPA is just one facet of the problem, as other bisphenol analogues, microplastics, nanoplastics and additional plastic derivatives also pose potential risks. Notably, BPA is implicated in every stage of non‐alcoholic fatty liver disease (NAFLD) onset and progression, surpassing hepatitis B virus as a primary cause of chronic liver disease worldwide. As plastic contamination tops the environmental contaminants list, urgent action is needed to assess causative factors and mitigate their impact. This review delves into the molecular disruptions linking plastic pollutant exposure to liver diseases, emphasizing the broader connection between plastics and the rising prevalence of NAFLD.

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Section: Bisphenols Endocrine Disruption and Carcinogenicitymentioning

confidence: 99%

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Sangwan,

Bhattacharyya,

Banerjee

2024

Liver International

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“…Chronic low-dose exposure to BPA throughout life has been associated with an increased risk of prostate disease. This can occur through interference with genes involved in intraprostatic androgen and estrogen production, as well as other genes implicated in PC development ( 361 – 363 ). Epigenetic markers, such as DNA methylation and histone modifications, may also contribute to these effects ( 364 ).…”

Section: Introductionmentioning

confidence: 99%

The adverse role of endocrine disrupting chemicals in the reproductive system

Pan,

Liu,

et al. 2024

Front. Endocrinol.

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Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation and changes in lifestyle, the occurrence of these diseases is closely connected to exposure to harmful substances in the environment. Endocrine disrupting chemicals (EDCs), characterized by hormone-like effects, have a wide range of influences on the reproductive system. EDCs are ubiquitous in the natural environment and are present in a wide range of industrial and everyday products. Currently, thousands of chemicals have been reported to exhibit endocrine effects, and this number is likely to increase as the testing for potential EDCs has not been consistently required, and obtaining data has been limited, partly due to the long latency of many diseases. The ability to avoid exposure to EDCs, especially those of artificially synthesized origin, is increasingly challenging. While EDCs can be divided into persistent and non-persistent depending on their degree of degradation, due to the recent uptick in research studies in this area, we have chosen to focus on the research pertaining to the detrimental effects on reproductive health of exposure to several EDCs that are widely encountered in daily life over the past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, and so on. By focusing on the impact of EDCs on the hypothalamic-pituitary-gonadal (HPG) axis, which leads to the occurrence and development of reproductive system diseases, this review aims to provide new insights into the molecular mechanisms of EDCs’ damage to human health and to encourage further in-depth research to clarify the potentially harmful effects of EDC exposure through various other mechanisms. Ultimately, it offers a scientific basis to enhance EDCs risk management, an endeavor of significant scientific and societal importance for safeguarding reproductive health.

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Unveiling bisphenol A toxicity: human health impacts and sustainable treatment strategies

Adhikary,

Kumari,

Chatterjee

et al. 2024

Hormone Molecular Biology and Clinical Investigation

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Introduction The widespread presence of bisphenol-A (BPA) in consumer goods like water bottles and eyeglass frames raises serious concerns about the chemical’s ability to accumulate in human tissues. Molecular filtration and activated carbon adsorption are two of the many BPA treatment technologies that have emerged in response to these issues; both are essential in the removal or degradation of BPA from water sources and industrial effluents. Content To secure the long-term health and environmental advantages of BPA treatment approaches, sustainable development is essential. Both the efficient elimination or destruction of BPA and the reduction of the treatment operations’ impact on the environment are important components of a sustainable approach. Different search engines like Pub-Med, MEDLINE, Google Scholar and Scopus are used for these systematic reviews and analyzed accordingly. This can be accomplished by making treatment facilities more energy efficient and using environmentally friendly materials. Greener ways to deal with BPA pollution are on the horizon, thanks to innovative techniques like bioremediation and improved oxidation processes. Reducing dependence on conventional, resource-intensive procedures can be achieved by investigating the use of bio-based materials and natural adsorbents in treatment processes. Summary and Outlook This review article tackling the health and environmental concerns raised by BPA calls for an integrated strategy that incorporates sustainable development principles and technology progress. We can reduce the negative impacts of BPA contamination, improve environmental stewardship in the long run, and ensure human health by combining cutting-edge treatment technologies with sustainable behaviours.

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Transcriptome-Wide Analysis of Low-Concentration Exposure to Bisphenol A, S, and F in Prostate Cancer Cells

Cited by 3 publications

References 65 publications

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

The adverse role of endocrine disrupting chemicals in the reproductive system

Unveiling bisphenol A toxicity: human health impacts and sustainable treatment strategies

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