2021
DOI: 10.2147/cmar.s324203
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Transcriptome Signature of Immune Cells Post Reovirus Treatment in KRAS Mutated Colorectal Cancer

Abstract: Purpose Reovirus propagates with high efficiency in KRAS mutated colorectal cancer (CRC). About 45–50% of CRC patients possess a KRAS mutation. Oncolytic reovirus treatment in combination with chemotherapy was tested in patients possessing KRAS mutated metastatic CRC. This study evaluates the biological responses to reovirus treatment by determining the gene expression patterns in RAS-related signaling pathways. … Show more

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Cited by 6 publications
(11 citation statements)
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“…TNFα-promoted apoptosis of cancer cells can also be induced through CASP9 upregulation through NF-κB and its target miR-1276 [40]. Our original research data showcased the fact that reovirus treatment was able to significantly increase apoptotic activity in KRAS mutated CRC through the heightened expression of CASP8 and CASP9 [11].…”
Section: Reovirus-induced Apoptosis Is Enacted Through the Actions Of...mentioning
confidence: 69%
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“…TNFα-promoted apoptosis of cancer cells can also be induced through CASP9 upregulation through NF-κB and its target miR-1276 [40]. Our original research data showcased the fact that reovirus treatment was able to significantly increase apoptotic activity in KRAS mutated CRC through the heightened expression of CASP8 and CASP9 [11].…”
Section: Reovirus-induced Apoptosis Is Enacted Through the Actions Of...mentioning
confidence: 69%
“…The oligomerization of the APAF1 protein at the onset of apoptosis is triggered by the binding of cytosolic cytochrome c, which prevents the autoinhibition of the APAF1 gene [31]. As indicated by our original research data, reovirus administration effectively promotes the expression of FAM96A and decrease the expression of VEGFB, thus inhibiting cell proliferation and angiogenesis [11].…”
Section: Post-reovirus the Expression Of Vegfb And Fam96a Results In ...mentioning
confidence: 85%
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