Transcriptome sequencing identified the ceRNA network associated with recurrent spontaneous abortion

Huang, Yong; Hao, Jiayuan; Liao, Yuan Jun; Zhou, Lihua; Wang, Kaiju; Zou, Hui; Hu, Ying; Li, Juan

doi:10.1186/s12920-021-01125-4

Cited by 11 publications

(9 citation statements)

References 41 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recurrent spontaneous abortion ANRIL decreases (122) Recurrent spontaneous abortion PVT1 decreases (122) Recurrent spontaneous abortion HOTAIR decreases (121) Recurrent spontaneous abortion SNHG5 decreases (119) Recurrent spontaneous abortion H19 increases (113) Recurrent spontaneous abortion MEG8 increases (122) Recurrent spontaneous abortion LINC01088 increases…”

Section: Discussionmentioning

confidence: 99%

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy

2024

Frontiers Research Topics

View full text Add to dashboard Cite

Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

show abstract

Section: Discussionmentioning

confidence: 99%

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy

2024

Frontiers Research Topics

View full text Add to dashboard Cite

show abstract

“…Our results showed that mRNA regulated URSA via multiple signaling pathways, including antigen processing and presentation, the Toll-like receptor signaling pathway, and Natural killer cell mediated cytotoxicity. Classically, activated macrophages in decidua are mainly involved in antigen processing and presentation ( Li et al, 2021 ) which has been shown to be associated with URSA ( Huang et al, 2021 ). Toll like receptors are a family of pattern recognition receptors, which play an essential role in maintaining innate host immunity and Th1/Th2 balance ( Koga and Mor, 2010 ; Chen et al, 2016 ), thereby permitting and accepting implanted and growing semi allogenic embryos.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of circRNAs, miRNAs, and mRNAs Expression Profiles and ceRNA Networks in Decidua of Unexplained Recurrent Spontaneous Abortion

Liu¹,

Wu²,

Nie³

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

The diagnosis and treatment of unexplained recurrent spontaneous abortion (URSA) are subject to debate, because the exact underlying mechanisms remain unclear. To address this issue, we elucidated the expression profiles of dysregulated circRNAs, miRNAs, and mRNAs and constructed circRNA-associated competitive endogenous RNA (ceRNA) networks by comparing the decidua of URSA with that of normal early pregnancy (NEP) using RNA-sequencing. In total, 550 mRNAs, 88 miRNAs, and 139 circRNAs were differentially expressed (DE) in decidua of URSA. Functional annotation revealed that DE mRNAs as well as potential target genes of DE miRNAs and DE circRNAs are mainly involved in immunologic function, such as antigen processing and presentation, allograft rejection, and T cell receptor signaling pathway. In addition, the top hub genes, including CCL4, DDX58, CXCL10, CXCL9, MX1, CD44, RPS2, SOCS3, RPS3A, and CXCL11, were identified. The mRNAs involved in ceRNA network were enriched in complement and coagulation cascades and protein processing in the endoplasmic reticulum. We found that circRNAs in the ceRNA network, which acted as decoys for hsa-miR-204-5p, were positively correlated with MFGE8 expression. Collectively, the results demonstrated that circRNAs, miRNAs, and mRNAs were aberrantly expressed in the decidua of patients with URSA and played a potential role in the development of URSA. Thus, the establishment of the ceRNA network may profoundly affect the diagnosis and therapy of URSA in the future.

show abstract

“…The lnc-SLC4A1-1 gene was discovered to be significantly expressed in the villi of URSA patients and to be able to trigger an immunological response via the NF-B/CXCL8 axis (117). In peripheral blood mononuclear cells from pregnant women with URSA, the expression levels of the lncRNAs SNHG5 and KLF4 were aberrant, and both of these were risk factors for the development of URSA (118,119). We discovered that the lncRNA types HOTAIR and SNHG7 are related to recurrent spontaneous abortion pathogenesis and control trophoblast proliferation, apoptosis, invasion, and chorionic villus angiogenesis (120,121).…”

Section: Exosomal Lncrna Offers Fresh Approaches To Identifying and T...mentioning

confidence: 99%

Biogenesis and function of exosome lncRNAs and their role in female pathological pregnancy

Wang,

Zheng,

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Preeclampsia, gestational diabetes mellitus, and recurrent spontaneous abortion are common maternal pregnancy complications that seriously endanger women’s lives and health, and their occurrence is increasing year after year with a rejuvenation trend. In contrast to biomarkers found freely in tissues or body fluids, exosomes exist in a relatively independent environment and provide a higher level of stability. As backbone molecules, guidance molecules, and signaling molecules in the nucleus, lncRNAs can regulate gene expression. In the cytoplasm, lncRNAs can influence gene expression levels by modifying mRNA stability, acting as competitive endogenous RNAs to bind miRNAs, and so on. Exosomal lncRNAs can exist indefinitely and are important in intercellular communication and signal transduction. Changes in maternal serum exosome lncRNA expression can accurately and timely reflect the progression and regression of pregnancy-related diseases. The purpose of this paper is to provide a reference for clinical research on the pathogenesis, diagnosis, and treatment methods of pregnancy-related diseases by reviewing the role of exosome lncRNAs in female pathological pregnancy and related molecular mechanisms.

show abstract

Transcriptome sequencing identified the ceRNA network associated with recurrent spontaneous abortion

Cited by 11 publications

References 41 publications

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy

Comprehensive Analysis of circRNAs, miRNAs, and mRNAs Expression Profiles and ceRNA Networks in Decidua of Unexplained Recurrent Spontaneous Abortion

Biogenesis and function of exosome lncRNAs and their role in female pathological pregnancy

Contact Info

Product

Resources

About