Transcriptome profiling of curcumin-treated T47D human breast cancer cells by a system-based approach

Khazei, Keyvan; M, Jamali; Sarhadi, Shamim; Dadashpour, Mehdi; Shokrollahzade, Soheila; Zarghami, Nosratollah

doi:10.1016/j.genrep.2022.101556

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…It inhibits proliferation in human BC cells (treated with T-47D curcumin) 87 , which is consistent with the biological process identified for the pink module. Moreover, ifit3 is considered a predictive biomarker for chemotherapy and radiation in some human cancers, such as breast, lung, prostate, neck, head cancer, and glioma 86 , 87 , indicating its potential utility across multiple cancer types. However, this is the first time that it has been identified as a potential biomarker associated with the Basal A subtype.…”

Section: Resultssupporting

confidence: 85%

Identification of modules and key genes associated with breast cancer subtypes through network analysis

Mares-Quiñones,

Galán-Vásquez,

Pérez-Rueda

et al. 2024

Sci Rep

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Breast cancer is the most common malignancy in women around the world. Intratumor and intertumoral heterogeneity persist in mammary tumors. Therefore, the identification of biomarkers is essential for the treatment of this malignancy. This study analyzed 28,143 genes expressed in 49 breast cancer cell lines using a Weighted Gene Co-expression Network Analysis to determine specific target proteins for Basal A, Basal B, Luminal A, Luminal B, and HER2 ampl breast cancer subtypes. Sixty-five modules were identified, of which five were characterized as having a high correlation with breast cancer subtypes. Genes overexpressed in the tumor were found to participate in the following mechanisms: regulation of the apoptotic process, transcriptional regulation, angiogenesis, signaling, and cellular survival. In particular, we identified the following genes, considered as hubs: IFIT3, an inhibitor of viral and cellular processes; ETS1, a transcription factor involved in cell death and tumorigenesis; ENSG00000259723 lncRNA, expressed in cancers; AL033519.3, a hypothetical gene; and TMEM86A, important for regulating keratinocyte membrane properties, considered as a key in Basal A, Basal B, Luminal A, Luminal B, and HER2 ampl breast cancer subtypes, respectively. The modules and genes identified in this work can be used to identify possible biomarkers or therapeutic targets in different breast cancer subtypes.

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Section: Resultssupporting

confidence: 85%

Identification of modules and key genes associated with breast cancer subtypes through network analysis

Mares-Quiñones,

Galán-Vásquez,

Pérez-Rueda

et al. 2024

Sci Rep

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“…In this regard, i t3 encodes for a transcription factor involved in the negative regulation of apoptotic processes and the negative regulation of cell proliferation 65,93 . It inhibits proliferation in human BC cells (treated with T-47D curcumin) 55 , which is consistent with the biological process identi ed for the pink module. Moreover, i t3 is considered a predictive biomarker for chemotherapy, and radiation in some human cancers, such as breast, lung, prostate, neck, head cancer, and glioma 122,93 .…”

Section: Correlation Network and Identi Cation Of Hub Genessupporting

confidence: 85%

Identification of modules and key genes associated with Breast Cancer subtypes through network analysis

Mares-Quiñones

Galán-Vásquez

Pérez‐Rueda

et al. 2023

Preprint

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Breast cancer is the most common malignancy in women around the world. Intratumor and intertumoral heterogeneity persist in mammary tumors. Therefore, the identification of biomarkers is essential for the treatment of this malignancy. This study analyzed 28,143 genes expressed in 49 breast cancer cell lines using a Weighted Gene Co-expression network analysis to determine specific target proteins for Basal A, Basal B, Luminal A, Luminal B and HER2 ampl breast cancer subtypes. Sixty-five modules were identified, of which five were characterized as having a high correlation with breast cancer subtypes. Genes overexpressed in the tumor were found to participate in the following mechanisms: regulation of the apoptotic process, transcriptional regulation, angiogenesis, signaling, and cellular survival. In particular, we identified the following genes, considered as hubs: IFIT3, an inhibitor of viral and cellular processes; ETS1, a transcription factor involved in cell death and tumorigenesis; ENSG00000259723 lncRNA, expressed in cancers; AL033519.3 a hypothetical gene; and TMEM86A, important for regulating keratinocyte membrane properties, considered as a key in Basal A, Basal B, Luminal A, Luminal B and HER2 ampl breast cancer subtypes, respectively. The modules and genes identified in this work can be used to identify possible biomarkers or therapeutic targets in different breast cancer subtypes.

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“…CUR, as a classical activator of Nrf2, is one of the well-investigated natural chemopreventive agents extracted from turmeric [ 144 ] (an Indian spice). CUR has a variety of therapeutic properties comprise of anti-oxidant [ 145 ], anti-inflammatory [ 146 , 147 ] and anti-cancer activities [ 148 , 149 ]. It also has been shown that CUR, via affecting the expression of AR, NQO1, GST, and HO-1, is able to activate a xenobiotic response in the cells [ 150 , 151 ].…”

Section: Nrf2 Activatorsmentioning

confidence: 99%

An update of Nrf2 activators and inhibitors in cancer prevention/promotion

Pouremamali

Dadashpour

et al. 2022

Cell Commun Signal

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NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription factor that defends against endogenous or exogenous stressors. By inducing several cytoprotective and detoxifying gene expressions, Nrf2 can increase the sensitivity of the cells to oxidants and electrophiles. Transient Nrf2 activation, by its specific activators, has protective roles against carcinogenesis and cancer development. However, permanent activation of Nrf2 promotes various cancer properties, comprising malignant progression, chemo/radio resistance, and poor patient prognosis. Taken together, these findings suggest that reaching an optimal balance between paradoxical functions of Nrf2 in malignancy may render a selective improvement to identify therapeutic strategies in cancer treatment. In this review, we describe lately discovered Nrf2 inducers and inhibitors, and their chemopreventive and/or anticancer activities.

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Transcriptome profiling of curcumin-treated T47D human breast cancer cells by a system-based approach

Cited by 4 publications

References 42 publications

Identification of modules and key genes associated with breast cancer subtypes through network analysis

Identification of modules and key genes associated with breast cancer subtypes through network analysis

Identification of modules and key genes associated with Breast Cancer subtypes through network analysis

An update of Nrf2 activators and inhibitors in cancer prevention/promotion

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