Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs

Colitti, Monica; Gaspardo, B.; Pria, A. Della; Scaini, Carlos James; Stefanon, Bruno

doi:10.1016/j.vetimm.2012.04.001

Cited by 42 publications

(36 citation statements)

References 39 publications

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“…This observation has also been made in animal models of OA 55,56 . We speculate that one explanation for the inflammatory plasma signature in a subset of SKOA patients is that PBLs are activated as a result of repeated exposure to inflammatory stimuli as they circulate through the diseased synovium and subchondral bone of affected joints.…”

Section: Discussionsupporting

confidence: 56%

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Attur

Statnikov

Samuels

et al. 2015

Osteoarthritis and Cartilage

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Objective Pro- and anti-inflammatory mediators, such as IL-1β and IL1Ra, are produced by joint tissues in osteoarthritis (OA), where they may contribute to pathogenesis. We examined whether inflammatory events occurring within joints are reflected in plasma of patients with symptomatic knee osteoarthritis (SKOA). Design 111 SKOA subjects with medial disease completed a 24-month prospective study of clinical and radiographic progression, with clinical assessment and specimen collection at 6-month intervals. The plasma biochemical marker IL1Ra was assessed at baseline and 18 months; other plasma biochemical markers were assessed only at 18 months, including IL-1β, TNFα, VEGF, IL-6, IL-6Rα, IL-17A, IL-17A/F, IL-17F, CRP, sTNF-RII, and MMP-2. Results In cross-sectional studies, WOMAC (total, pain, function) and plasma IL1Ra were modestly associated with radiographic severity after adjustment for age, gender and BMI. In addition, elevation of plasma IL1Ra predicted joint space narrowing (JSN) at 24 months. BMI did associate with progression in some but not all analyses. Causal graph analysis indicated a positive association of IL1Ra with JSN; an interaction between IL1Ra and BMI suggested either that BMI influences IL1Ra or that a hidden confounder influences both BMI and IL1Ra. Other protein biomarkers examined in this study did not associate with radiographic progression or severity. Conclusions Plasma levels of IL1Ra were modestly associated with the severity and progression of symptomatic knee osteoarthritis in a causal fashion, independent of other risk factors. The findings may be useful in the search for prognostic biomarkers and development of disease-modifying OA drugs.

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Section: Discussionsupporting

confidence: 56%

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Attur

Statnikov

Samuels

et al. 2015

Osteoarthritis and Cartilage

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“…Many natural phytonutrients have beneficial effects on health [1,2]. In addition, several botanicals have received positive attention, based on their relative safety and the accumulation of evidence of their antiadipogenic and metabolic effects in animals and humans [3].…”

Section: Editorialmentioning

confidence: 99%

Rhodiola Rosea: From the Adaptogenic Role to the Anti-Adipogenic Effect?

Colitti¹

2014

Endocrinol Metab Syndr

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EditorialMany natural phytonutrients have beneficial effects on health [1,2]. In addition, several botanicals have received positive attention, based on their relative safety and the accumulation of evidence of their antiadipogenic and metabolic effects in animals and humans [3]. Natural products can decrease of lipid absorption, energy intake, lipogenesis, pre-adipocyte differentiation and proliferation or increase of energy expenditure, and lipolysis [4]. These properties exist in specific flavonoids [5], chlorogenic acid from green coffee bean [6], and carnosic acid in rosemary [7]. Extracts from Rhodiola rosea (RR) root is poorly characterized for its properties on adipocytes and only recently it has been proposed for a the adjuvant treatment of obesity against obesity [8].RR is a popular plant in traditional medical systems in the Nordic countries, Eastern Europe and Asia. It belongs to the family of Crassulaceae with a notoriety for stimulating physical endurance, attention span, memory, and work productivity [9][10][11]. The genus Rhodiola contains more than 100 different species, and at least 20 of these are used in traditional Asian medicine [12,13]. However, the most of all animal and human studies has been conducted on RR, so whether other species confer the same health benefits is unknown [14,15].Researches on the RR root phytochemistry has revealed the presence of six distinct groups of chemical compounds: phenylpropanoids (rosavin, rosin, rosarin), phenylethanol derivatives (salidroside, tyrosol); flavonoids (rodiolin, rodionin, rodiosin, acetylrodalgin, tricin), monoterpernes (rosiridol, rosaridin), triterpenes (daucosterol, beta-sitosterol) and phenolic acids (chlorogenic and hydroxycinnamic, gallic acids) [9,16].According to the Soviet Pharmacopeia [17,18], the extracts of RRprimarily in the form of water/alcohol tinctures or dried root extractare standardized for both rosavins and salidroside. RR extracts used in most human clinical studies were standardized to minimum 3% rosavins and 0.8-1% salidroside, because the naturally occurring ratio of these compounds in RR root is approximately 3:1 [14].The main effects of genus Rhodiola described are adaptogenic that means 'natural herbal products which are non-toxic in normal doses, produce a non-specific response, and have a normalizing physiologic influence' and stress protective [19,20]. Moreover, Rhodiola has been described as antioxidant [21][22][23] [32,33], and immunostimulating [34][35][36]. Recently, many other benefits from the use of RR has been found including its ability to regulate blood sugar levels for diabetics and to activate the lipolytic processes [37], mobilizing lipids from adipose tissue to the natural fat burning system of body for weight reduction [8]. In combination with Citrus aurantium, RR has been found to decrease visceral fat weight by 30% of rats fed with high fat diet, having a direct effect on sympathetic tone and on hypothalamic norepinephrine secretion [8]. Although detailed molecular mechanism of the lipid loweri...

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“…In the past two decades, among all nutraceuticals, glucosamine and chondroitin sulfate have been predominantly used in the treatment of canine OA [13,[58][59][60][61]. In clinical trials, nutraceuticals such as glucosamine and chondroitin sulfate and/or undenatured type II collagen [13,[60][61][62] Crominex® -3+ [16] purified shilajit [30], avocado/soybean unsaponifiables [63], green lipped mussel [35,64] and curcumin [65] have been found significantly effective in ameliorating OA pain and have shown to be safe for long-term use in canines.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Terminalia chebula Extract for Anti-Arthritic Efficacy and Safety in Osteoarthritic Dogs

Murdock¹,

Vega³

et al. 2015

J Veterinar Sci Technol

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The present investigation was undertaken to assess anti-inflammatory and anti-arthritic efficacy and safety of T. chebula extract (TCE) in moderately osteoarthritic (OA) dogs. Dogs with OA received either 500 mg placebo or 500 mg TCE twice daily for 150 days. On a monthly basis, dogs were given a full physical exam and were evaluated for arthritic pain (overall pain, pain upon limb manipulation, and pain after physical exertion), inflammation (erythrocyte sedimentation rate, ESR), and analysis of complete blood count (CBC) and serum biomarkers of liver (bilirubin, ALT, and AST), kidney (BUN and creatinine), and heart and skeletal muscle (CK) functions. Elbow and stifle joints were radiographed on day 0 and day 150 for evaluation of arthritic progression. Dogs given TCE showed significant (P<0.01) reductions in overall pain, pain upon limb manipulation, and pain after physical exertion by day 90, with maximum effects on day 150 (81.2%, 81.5%, and 84.2%, respectively). A marked reduction in ESR coincided with pain reduction in TCE-treated dogs, which was indicative of anti-inflammatory effect of TCE. Radiographic evidence also indicated slowed progression of OA in joints examined. No significant change occurred in physical parameters, CBC parameters, or serum biomarkers in dogs on placebo or treatment, which suggested that TCE was well tolerated. It can be concluded that TCE, by having many active principles (chebulagic acid, chebulinic acid, corilagin, hydrolysable tannoids, etc.) might have provided antioxidant, anti-inflammatory and anti-arthritic effects in dogs without causing any side effects.

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Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs

Cited by 42 publications

References 39 publications

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Rhodiola Rosea: From the Adaptogenic Role to the Anti-Adipogenic Effect?

Evaluation of Terminalia chebula Extract for Anti-Arthritic Efficacy and Safety in Osteoarthritic Dogs

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