Transcriptome diversity and differential expression in supporting limb laminitis

Holl, Heather M.; Armstrong, Caren; Galantino‐Homer, Hannah; Brooks, Samantha A.

doi:10.1016/j.vetimm.2021.110353

Cited by 1 publication

(1 citation statement)

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“…The fourth paper applied RNAseq with the highest quality samples (4 pooled from each phenotype) undergoing long read sequencing to look for differentially expressed genes in lamellar tissues (36 samples) from 13 horses suffering from SLL (hospital‐acquired) compared with seven control horses (subjected to euthanasia for lameness due to nonlaminitic orthopaedic disease) 64 . Each animal and limb from which the lamellar tissue was derived was scored from clinical, gross and histopathological findings as having no laminitis, developmental laminitis (no clinical signs but some histopathological lesions) or acute laminitis.…”

Section: Discovery Of Pathophysiological Pathways Through Transcripto...mentioning

confidence: 99%

A review of cellular and molecular mechanisms in endocrinopathic, sepsis‐related and supporting limb equine laminitis

Elliott

Bailey

2023

Equine Veterinary Journal

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Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture‐associated laminitis have an insulin‐dysregulated phenotype (endocrinopathic laminitis, EL) and that prolonged insulin and glucose infusions can experimentally induce laminar pathology and functional failure are seminal discoveries in this field. Researchers have studied the molecular basis for disease pathogenesis in models of EL, sepsis‐related laminitis and supporting limb laminitis and generated much data over the last 15 years. This review attempts to synthesise those data, drawing comparisons between models and naturally occurring laminitis. A hypothesis is proposed that the basal epithelial cell stress is a central event in each category of laminitis. Furthermore, in naturally occurring pasture‐associated laminitis, pathways that predominate in each type of laminitis contribute to laminar lamellar pathology to varying extents. Based on the molecular mechanisms determined in experimental models, interactions between these pathways are identified.

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Section: Discovery Of Pathophysiological Pathways Through Transcripto...mentioning

confidence: 99%

A review of cellular and molecular mechanisms in endocrinopathic, sepsis‐related and supporting limb equine laminitis

Elliott

Bailey

2023

Equine Veterinary Journal

View full text Add to dashboard Cite

show abstract

Transcriptome diversity and differential expression in supporting limb laminitis

Cited by 1 publication

References 93 publications

A review of cellular and molecular mechanisms in endocrinopathic, sepsis‐related and supporting limb equine laminitis

A review of cellular and molecular mechanisms in endocrinopathic, sepsis‐related and supporting limb equine laminitis

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